Rbm38, an RNA-binding protein, mainly regulates gene expression post-transcriptionally. It can also act on chromatin as a transcription factor or co-factor. Rbm38 is involved in various biological processes and is of great significance in maintaining normal cellular functions [1,4,8]. Genetic mouse models have been crucial in understanding its functions.

In cancer research, Rbm38 frequently acts as a tumor suppressor. Mice deficient in Rbm38, especially in combination with different p53 status, have shown an increased incidence of spontaneous tumors, establishing Rbm38 as a tumor suppressor [1,5]. In hepatocellular carcinoma, Rbm38 can reverse sorafenib resistance by binding to and promoting lncRNA-GAS5 [2]. In breast cancer, miR-320b negatively regulates Rbm38, and Rbm38 overexpression enhances adriamycin resistance [3]. In acute myeloid leukemia cells HL-60, Rbm38 promotes cell proliferation by regulating FZD1 mRNA stability [6]. In malignant melanoma, high expression of Rbm38 promotes cell proliferation, invasion, and migration [7].

In conclusion, Rbm38 plays a vital role in tumor suppression as demonstrated by gene-knockout mouse models in multiple cancer types. It is also involved in processes like drug resistance in cancer cells. Understanding Rbm38's functions provides potential therapeutic strategies against cancer.