C57BL/6JCya-Hdac7em1flox/Cya
Common Name:
Hdac7-flox
Product ID:
S-CKO-11995
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Hdac7-flox
Strain ID
CKOCMP-56233-Hdac7-B6J-VA
Gene Name
Product ID
S-CKO-11995
Gene Alias
5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Hdac7em1flox/Cya mice (Catalog S-CKO-11995) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000116409
NCBI RefSeq
NM_001204275
Target Region
Exon 5~11
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
HDAC7, a member of the histone deacetylase family, is a "pseudodeacetylase" due to mutation of a catalytic tyrosine, and its functions are attributed to scaffolding roles [7]. It is involved in multiple cellular pathophysiological processes, and can activate relevant signaling pathways by exerting deacetylation [2].
In cancer research, HDAC7 has been shown to promote the progression of various tumors. In NSCLC, it promotes proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of the β -catenin-FGF18 pathway [1]. In ESCC, HDAC7 forms a positive feedback loop with β -catenin and c-Myc, and its protein stability is maintained by USP10 to enhance cell growth [3]. In ovarian cancer, HDAC7 promotes malignancy through the AKT/mTOR signalling pathway [6]. In choroidal melanoma cells, the HDAC7/c-Myc signaling pathway promotes cell proliferation and metastasis [9]. Also, in DLBCL, HDAC7 expression is associated with prognosis and immune infiltration [4].
In addition to cancer, in macrophages, HDAC7 acts as an immunometabolic switch, triaging danger signals for appropriate immune responses [5]. In astrocytes, HDAC7 activates the IKK/NF-κB signaling to regulate inflammation [8].
In conclusion, HDAC7 is involved in diverse biological processes, especially playing crucial roles in cancer progression, immune responses, and inflammation. Research on HDAC7 using various models helps to understand its functions and provides potential therapeutic targets for related diseases.
References:
1. Guo, Kai, Ma, Zhiqiang, Zhang, Yujiao, Li, Xiaofei, Yan, Xiaolong. 2022. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. In Journal of experimental & clinical cancer research : CR, 41, 91. doi:10.1186/s13046-022-02266-9. https://pubmed.ncbi.nlm.nih.gov/35277183/
2. Liu, Cui, Zheng, Dan, Pu, Xuan, Li, Sijun. 2024. HDAC7: a promising target in cancer. In Frontiers in oncology, 14, 1327933. doi:10.3389/fonc.2024.1327933. https://pubmed.ncbi.nlm.nih.gov/38487728/
3. Ma, Zhi-Qiang, Feng, Ying-Tong, Guo, Kai, Yan, Xiao-Long, Hu, Yi. 2022. Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. In Military Medical Research, 9, 54. doi:10.1186/s40779-022-00412-0. https://pubmed.ncbi.nlm.nih.gov/36163081/
4. Lu, Weiguo, Zhuang, Guangyan, Guan, Youmin, Liu, Liujun, Xiao, Mingfeng. . Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma: A review. In Medicine, 102, e34577. doi:10.1097/MD.0000000000034577. https://pubmed.ncbi.nlm.nih.gov/37960766/
5. Das Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B, Fairlie, David P, Sweet, Matthew J. 2023. HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. In Proceedings of the National Academy of Sciences of the United States of America, 120, e2212813120. doi:10.1073/pnas.2212813120. https://pubmed.ncbi.nlm.nih.gov/36649417/
6. Feng, Qi, Hao, Sheng, Liu, Xiongxiu, Zhang, Peng, Sheng, Xiugui. . HDAC7 promotes ovarian cancer malignancy via AKT/mTOR signalling pathway. In Journal of cellular and molecular medicine, 28, e70120. doi:10.1111/jcmm.70120. https://pubmed.ncbi.nlm.nih.gov/39431349/
7. Kodikara, Ishadi K M, Pflum, Mary Kay H. 2025. Scaffolding Activities of Pseudodeacetylase HDAC7. In ACS chemical biology, 20, 248-258. doi:10.1021/acschembio.4c00753. https://pubmed.ncbi.nlm.nih.gov/39908122/
8. Ye, Jinwang, Zhong, Suyue, Deng, Yunsong, Wang, Jian-Zhi, Xiao, Shifeng. 2022. HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. In Molecular neurobiology, 59, 6141-6157. doi:10.1007/s12035-022-02965-6. https://pubmed.ncbi.nlm.nih.gov/35871708/
9. Zhang, Yimeng, Ding, Peng, Wang, Yuanyong, Ma, Zhiqiang, Han, Jing. 2023. HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells. In Cell death & disease, 14, 38. doi:10.1038/s41419-022-05522-0. https://pubmed.ncbi.nlm.nih.gov/36653340/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen