C57BL/6JCya-Rbms1em1flox/Cya
Common Name:
Rbms1-flox
Product ID:
S-CKO-12265
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Rbms1-flox
Strain ID
CKOCMP-56878-Rbms1-B6J-VA
Gene Name
Product ID
S-CKO-12265
Gene Alias
2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbms1em1flox/Cya mice (Catalog S-CKO-12265) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028347
NCBI RefSeq
NM_020296
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
RBMS1, short for RNA binding motif single strand interacting protein 1, is an RNA-binding protein. It is involved in multiple biological processes, such as translational control, mRNA stability regulation, and is associated with pathways like ferroptosis, autocrine IL-6/JAK2/STAT3 signaling, and immune-related pathways. Its functions have significant implications for cancer development, cellular senescence, and other biological conditions, making genetic models crucial for its study.
In cancer research, depletion of RBMS1 has shown multiple beneficial effects. In lung cancer, it inhibits cancer progression by promoting ferroptosis through translational control of SLC7A11 [1]. In gastric cancer, silencing RBMS1 can block its metastasis-promoting effect via autocrine IL-6/JAK2/STAT3 signaling [2]. In triple-negative breast cancer, loss of RBMS1 enhances anti-tumor immunity by enabling PD-L1 checkpoint blockade [3]. In glioblastoma, RBMS1 interference inhibits cell malignant progression and promotes ferroptosis [4]. In colorectal cancer, inhibiting the RBMS1/PRNP axis improves oxaliplatin chemoresistance by enhancing ferroptosis [5].
In conclusion, RBMS1 plays a complex role in various biological processes, especially in cancer. Model-based research, including gene knockout or conditional knockout mouse models, has revealed its significance in promoting or suppressing cancer progression through different mechanisms, providing potential therapeutic targets for multiple cancer types.
References:
1. Zhang, Wenjing, Sun, Yu, Bai, Lu, Liu, Han, Wang, Yang. . RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. In The Journal of clinical investigation, 131, . doi:10.1172/JCI152067. https://pubmed.ncbi.nlm.nih.gov/34609966/
2. Liu, Mengyuan, Li, Heming, Zhang, Huijing, Xue, Lei, Xu, Lu. 2022. RBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling. In Cell death & disease, 13, 287. doi:10.1038/s41419-022-04747-3. https://pubmed.ncbi.nlm.nih.gov/35361764/
3. Zhang, Jinrui, Zhang, Ge, Zhang, Wenjing, Liu, Han, Wang, Yang. 2022. Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer. In Cell death and differentiation, 29, 2247-2261. doi:10.1038/s41418-022-01012-0. https://pubmed.ncbi.nlm.nih.gov/35538152/
4. Liang, Xiaosong, Wang, Gang, Xue, Chunxiao, Zhou, Yifu. 2024. RBMS1 interference inhibits malignant progression of glioblastoma cells and promotes ferroptosis. In Discover oncology, 15, 548. doi:10.1007/s12672-024-01430-1. https://pubmed.ncbi.nlm.nih.gov/39392522/
5. Xu, Yini, Hao, Jingpeng, Chen, Qiang, Zhang, Jingyi, Wang, Hao. 2023. Inhibition of the RBMS1/PRNP axis improves ferroptosis resistance-mediated oxaliplatin chemoresistance in colorectal cancer. In Molecular carcinogenesis, 63, 224-237. doi:10.1002/mc.23647. https://pubmed.ncbi.nlm.nih.gov/37861356/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen