Sap30bp, a factor with relatively less-characterized functions previously, has emerged as significant in multiple biological processes. It is involved in the regulation of pre-mRNA splicing and may also play a role in histone deacetylase activity regulation in plants [1,8]. In the context of human pre-mRNA splicing, it is associated with the splicing process of a subset of short introns and acts as a critical activator of CDK11, a druggable target for cancer therapy [1,2].

In a case-control study based on the Han Chinese population, the genetic polymorphism of SAP30BP, specifically SNP rs820218, was found to be associated with the susceptibility of rotator cuff tear, with the A allele conferring less susceptibility [3]. However, in an Amazonian population, an association of the genetic variant rs820218 of the SAP30BP gene with rotator cuff tears was not established, though the presence of the A allele still indicated protection [4]. Multiple reviews also suggest the need for further investigation into the association between SAP30BP rs820218 and rotator cuff injuries [5,6,7].

In conclusion, Sap30bp has essential functions in pre-mRNA splicing regulation, potentially through its role as a CDK11 activator. Its genetic polymorphisms are associated with the susceptibility of rotator cuff tears, though more research is needed to clarify this relationship. Understanding Sap30bp can provide insights into RNA splicing-related biological processes and potentially into the genetic basis of rotator cuff-related diseases.