C57BL/6JCya-Sec61a2em1flox/Cya
Common Name:
Sec61a2-flox
Product ID:
S-CKO-12344
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Sec61a2-flox
Strain ID
CKOCMP-57743-Sec61a2-B6J-VA
Gene Name
Product ID
S-CKO-12344
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sec61a2em1flox/Cya mice (Catalog S-CKO-12344) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102981
NCBI RefSeq
NM_021305
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Sec61a2 encodes the α -subunit of the heterotrimeric Sec61 translocon, which forms the actual protein-conducting channel. It is involved in protein translocation into the endoplasmic reticulum and plays a role in maintaining blood glucose homeostasis, potentially in association with diabetes-related pathways [1].
In pancreatic β-cells, Sec61a2 has a greater impact on proinsulin biosynthesis compared to its paralog Sec61α1. Sec61α2 translocon deficiency significantly inhibits preproinsulin biosynthesis, leading to a disproportionate increase of full-length nascent chain unreleased from ribosomes [1].
In summary, Sec61a2 is crucial for proinsulin biosynthesis in pancreatic β-cells, with its deficiency affecting the production of preproinsulin. This role in insulin-related processes highlights its potential significance in understanding and addressing diabetes-related conditions.
References：
1. Xu, Xiaoxi, Bell, Thomas W, Le, Truc, Liu, Ming, Arvan, Peter. . Role of Sec61α2 Translocon in Insulin Biosynthesis. In Diabetes, 73, 2034-2044. doi:10.2337/db24-0115. https://pubmed.ncbi.nlm.nih.gov/39325584/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen