C57BL/6JCya-Sectm1bem1flox/Cya
Common Name:
Sectm1b-flox
Product ID:
S-CKO-12407
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Sectm1b-flox
Strain ID
CKOCMP-58210-Sectm1b-B6J-VA
Gene Name
Product ID
S-CKO-12407
Gene Alias
1810003C24Rik; K12; Sectm1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sectm1bem1flox/Cya mice (Catalog S-CKO-12407) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000039309
NCBI RefSeq
NM_026907
Target Region
Exon 3~4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
SECTM1B, along with SECTM1A, is a ligand that binds strongly to CD7 [1]. It is involved in modulating T-cell activation, opposing the co-stimulatory effect of SECTM1A, as it proves inhibitory to TCR-mediated T-cell activation [1]. This function may potentially regulate the activation of effector and regulatory T cells, suggesting its importance in the immune response pathways.
SECTM1B was able to compete with SECTM1A for CD7 binding, and both ligands' functional outcomes on T-cell activation were CD7-independent, indicating the existence of alternative receptors [1]. Nucleotide substitution analysis provided evidence for positive selection in SECTM1B, which may be related to its immunological and reproductive functions as suggested by gene expression profiles and homologous sequence annotations [2]. During pneumococcal pneumonia, related Sectm1 genes (including Sectm1b) were induced in conducting airway epithelial cells, with Sectm1a (a related protein) binding to myeloid cells in infected lungs [3].
In conclusion, SECTM1B plays a role in modulating T-cell activation, potentially through alternative receptors. Its positive selection and expression patterns suggest immunological and reproductive functions. In the context of pneumococcal pneumonia, its related genes are induced in airway epithelial cells. The study of SECTM1B using genetic models can help further understand its role in immune-related and reproductive biological processes and potentially in disease conditions such as pneumonia.
References:
1. Howie, Duncan, Garcia Rueda, Hugo, Brown, Marion H, Waldmann, Herman. 2013. Secreted and transmembrane 1A is a novel co-stimulatory ligand. In PloS one, 8, e73610. doi:10.1371/journal.pone.0073610. https://pubmed.ncbi.nlm.nih.gov/24039998/
2. Larson, Joshua H, Kumar, Charu G, Everts, Robin E, Band, Mark R, Lewin, Harris A. 2006. Discovery of eight novel divergent homologs expressed in cattle placenta. In Physiological genomics, 25, 405-13. doi:. https://pubmed.ncbi.nlm.nih.gov/16554549/
3. Kamata, Hirofumi, Yamamoto, Kazuko, Wasserman, Gregory A, Jones, Matthew R, Mizgerd, Joseph P. . Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. In American journal of respiratory cell and molecular biology, 55, 407-18. doi:10.1165/rcmb.2015-0261OC. https://pubmed.ncbi.nlm.nih.gov/27064756/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen