Cables1, short for Cdk5 and Abl enzyme substrate 1, is an adaptor protein that links cyclin-dependent kinases (Cdks) with non-receptor tyrosine kinases. It regulates Cdk activity by enhancing Y15 phosphorylation. Cables1 can interact with various proteins like p53 family proteins, 14-3-3, and β-catenin, suggesting it may be a signaling hub for cell growth regulation [1].

In mice, Cables1-deficient young mice show hyperproliferation of hematopoietic progenitor cells, indicating its role in hematopoietic homeostasis. Aged Cables1-deficient mice have abnormal peripheral blood cell counts and reduced HSC compartment [2]. In zebrafish, knockdown of cables1 leads to increased apoptosis in brain tissue and a hyperactive behavioral phenotype, suggesting its importance in embryonic neural development [3]. Also, truncated Cables1 in mice causes agenesis of the corpus callosum [4].

In conclusion, Cables1 is crucial for multiple biological processes. Studies using gene-knockout models in mice and zebrafish have revealed its roles in hematopoietic homeostasis, embryonic neural development, and brain structure formation. These findings contribute to understanding the mechanisms of related diseases such as hematopoietic disorders and congenital brain abnormalities.