C57BL/6JCya-Mrps10em1flox/Cya
Common Name:
Mrps10-flox
Product ID:
S-CKO-12775
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mrps10-flox
Strain ID
CKOCMP-64657-Mrps10-B6J-VA
Gene Name
Product ID
S-CKO-12775
Gene Alias
1110038B19Rik; Rpms10
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrps10em1flox/Cya mice (Catalog S-CKO-12775) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000119945
NCBI RefSeq
NM_001146212
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Overview of Gene Research
Mrps10, a mitochondrial ribosomal protein gene, is an essential component for the structural and functional integrity of the mitoribosome complex. Mitoribosomes play a crucial role in mitochondrial translation, which is vital for the synthesis of proteins involved in oxidative phosphorylation and energy production. As part of the mitoribosome, Mrps10 is thus important for normal mitochondrial function and overall cellular metabolism [1].
In a study on pigs, MRPS10 was identified as a hub gene in a protein-protein interaction network related to abdominal subcutaneous fat deposition. It was also considered a potential obese-specific biomarker, suggesting its role in fat metabolism-related biological processes [3]. In thyroid cancer, lower expression of MRPS10 was observed, and it was part of a senescence-related signature that could predict prognosis and immunotherapy response, indicating its possible involvement in cancer-related biological behaviors [2]. In rheumatoid arthritis, MRPS10 was one of the validated biomarkers related to energy and reactive oxygen species (ROS) metabolism, linked to oxidative phosphorylation, and may be involved in the pathogenesis of the disease [4]. In a study on intensive care unit-acquired weakness, miR-542-3p suppressed the expression of MRPS10, leading to mitochondrial ribosomal stress, suggesting its importance in muscle-related mitochondrial function [5]. In a cancer cell line panel study, overexpression of MRPS10 was found in breast cancer, and its protein-protein interactions indicated a putative role in fatty acid oxidation regulated by the brain-derived neurotrophic factor signaling pathway [6].
In conclusion, Mrps10 is crucial for mitoribosome function and cellular metabolism. Its role has been implicated in various disease conditions such as obesity-related fat deposition, thyroid cancer, rheumatoid arthritis, muscle-related mitochondrial function in intensive care unit-acquired weakness, and breast cancer. These findings from different research models help to understand the diverse biological functions of Mrps10 and its potential significance in disease mechanisms.
References：
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. Hong, Kai, Cen, Kenan, Chen, Qiaoqiao, Mai, Yifeng, Guo, Yangyang. 2023. Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy. In Frontiers in immunology, 14, 1128390. doi:10.3389/fimmu.2023.1128390. https://pubmed.ncbi.nlm.nih.gov/36761753/
3. Yang, Yongli, Wang, Xiaoyi, Li, Mingli, Chen, Qiang, Lu, Shaoxiong. 2024. Identification of potential obese-specific biomarkers and pathways associated with abdominal subcutaneous fat deposition in pig using a comprehensive bioinformatics strategy. In PeerJ, 12, e17486. doi:10.7717/peerj.17486. https://pubmed.ncbi.nlm.nih.gov/38832038/
4. Gao, Conghui, Zhang, Chengqiang, Wen, Lixing, Duan, Jiaoniu, Guo, Yingying. 2025. Regulation of reactive oxygen species and the role of mitochondrial apoptotic-related genes in rheumatoid arthritis. In Scientific reports, 15, 2165. doi:10.1038/s41598-025-85460-x. https://pubmed.ncbi.nlm.nih.gov/39820483/
5. Garros, Roser Farre, Paul, Richard, Connolly, Martin, Polkey, Michael I, Kemp, Paul R. . MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness. In American journal of respiratory and critical care medicine, 196, 1422-1433. doi:10.1164/rccm.201701-0101OC. https://pubmed.ncbi.nlm.nih.gov/28809518/
6. Revathi Paramasivam, Oviya, Gopisetty, Gopal, Subramani, Jayavelu, Thangarajan, Rajkumar. . Expression and affinity purification of recombinant mammalian mitochondrial ribosomal small subunit (MRPS) proteins and protein-protein interaction analysis indicate putative role in tumourigenic cellular processes. In Journal of biochemistry, 169, 675-692. doi:10.1093/jb/mvab004. https://pubmed.ncbi.nlm.nih.gov/34492114/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen