C57BL/6JCya-Lpin3em1flox/Cya
Common Name:
Lpin3-flox
Product ID:
S-CKO-12788
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lpin3-flox
Strain ID
CKOCMP-64899-Lpin3-B6J-VA
Gene Name
Product ID
S-CKO-12788
Gene Alias
9130206L11Rik; mKIAA4023
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lpin3em1flox/Cya mice (Catalog S-CKO-12788) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000040872
NCBI RefSeq
NM_001199118
Target Region
Exon 4~7
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Lpin3, encoding phosphatidate phosphatase type 1 enzyme, is involved in lipid metabolism, playing a role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine [6]. It has been associated with various biological processes and diseases, and genetic models are valuable for studying its functions.
In colorectal cancer, LPIN3 is highly expressed and promotes tumor growth. LPIN3 knockdown in vivo strengthened CD8+ T cell-mediated cytotoxicity, infiltration and activation, indicating that LPIN3 may drive CRC progression by regulating β-catenin signaling and CD8+ T cell activity [1].
In a male infant, an LPIN3 mutation was associated with failure to thrive [2].
In liver transplantation, LPIN3 was among the key proteins differentially expressed between early allograft dysfunction (EAD) and non-EAD groups, with potential implications for assessing graft quality and predicting EAD [3].
In Chinese fat-tailed sheep, Lpin3 mRNA was prominently expressed in liver and small intestine, and its expression was associated with slaughter and tail traits [4]. A novel cell-penetrating peptide was identified from human LPIN3, which could potentially be used in drug delivery systems [5].
In conclusion, Lpin3 plays essential roles in lipid metabolism, and its dysregulation is associated with diseases like colorectal cancer and growth disorders. Studies, including those using in vivo models, have provided insights into its functions in specific biological processes and disease conditions, contributing to our understanding of related disease mechanisms.
References：
1. Zhang, Xiaoming, Fang, Hao, Wu, Wenliang, Wang, Haizhou, Shi, Yifei. 2025. LPIN3 promotes colorectal cancer growth by dampening intratumoral CD8+ T cell effector function. In Cancer immunology, immunotherapy : CII, 74, 135. doi:10.1007/s00262-025-03989-2. https://pubmed.ncbi.nlm.nih.gov/40042548/
2. Altay, Derya, Gorukmez, Orhan, Arslan, Duran. 2020. Coexistence of Three Different Mutations in a Male Infant: neurofibromatosis Type 1, Progressive Familial Intrahepatic Cholestasis Type 2 and LPIN3. In Fetal and pediatric pathology, 41, 293-298. doi:10.1080/15513815.2020.1783405. https://pubmed.ncbi.nlm.nih.gov/32597698/
3. Lin, Yimou, Huang, Haitao, Cao, Jiaying, Zheng, Shusen, Ling, Qi. 2024. An integrated proteomics and metabolomics approach to assess graft quality and predict early allograft dysfunction after liver transplantation: a retrospective cohort study. In International journal of surgery (London, England), 110, 3480-3494. doi:10.1097/JS9.0000000000001292. https://pubmed.ncbi.nlm.nih.gov/38502860/
4. Jiao, Xiao-Li, Jing, Jiong-Jie, Qiao, Li-Ying, Jia, Xia-Li, Liu, Wen-Zhong. 2016. Ontogenetic Expression of Lpin2 and Lpin3 Genes and Their Associations with Traits in Two Breeds of Chinese Fat-tailed Sheep. In Asian-Australasian journal of animal sciences, 29, 333-42. doi:10.5713/ajas.15.0467. https://pubmed.ncbi.nlm.nih.gov/26950863/
5. Lim, Sangho, Kim, Won-ju, Kim, Yeon-ho, Choi, Je-Min. 2012. Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3. In Molecules and cells, 34, 577-82. doi:10.1007/s10059-012-0284-y. https://pubmed.ncbi.nlm.nih.gov/23263658/
6. He, Xiaoping, Xu, Xuewen, Liu, Bang. 2008. Molecular characterization, chromosomal localization and association analysis with back-fat thickness of porcine LPIN2 and LPIN3. In Molecular biology reports, 36, 1819-24. doi:10.1007/s11033-008-9385-2. https://pubmed.ncbi.nlm.nih.gov/18989753/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen