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C57BL/6JCya-Lrp10em1flox/Cya
Common Name:
Lrp10-flox
Product ID:
S-CKO-12803
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lrp10-flox
Strain ID
CKOCMP-65107-Lrp10-B6J-VA
Gene Name
Lrp10
Product ID
S-CKO-12803
Gene Alias
Lrp9
Background
C57BL/6JCya
NCBI ID
65107
Modification
Conditional knockout
Chromosome
14
Phenotype
MGI:1929480
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrp10em1flox/Cya mice (Catalog S-CKO-12803) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022782
NCBI RefSeq
NM_022993
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lrp10, the low-density lipoprotein receptor-related protein 10, encodes a conserved cell surface protein. It has an impact on CD8 T-cell fate by suppressing IL7R levels post-translationally, thus influencing CD8 T-cell homeostatic expansion and anti-tumor immunity [1]. In the context of the nervous system, it may be involved in intracellular vesicle trafficking pathways through interaction with SORL1 in non-neuronal brain cells [2].

Forward genetic screening in mice showed that loss-of-function mutations in Lrp10 lead to the accumulation of naive and central memory CD8 T cells in peripheral lymphoid organs. Lrp10-deficient mice are resistant to syngeneic tumors due to dense CD8 T-cell infiltration with enhanced memory cell characteristics and reduced terminal exhaustion [1]. In neurodegenerative diseases, Lrp10 variants have been associated with Parkinson's disease (PD), PD dementia, dementia with Lewy bodies (DLB), progressive supranuclear palsy, and amyotrophic lateral sclerosis. In non-neuronal brain cells of control subjects, Lrp10 is highly expressed, while in neurons, it is undetectable. In some PD and DLB patients with Lrp10 variants, enlarged LRP10-positive vesicles were detected, and LRP10 was found in Lewy bodies at late maturation stages [2]. Also, in LBDs, wild-type LRP10 is secreted via extracellular vesicles and can be internalized. LRP10 overexpression affects α-synuclein levels, and a patient-derived LRP10 variant binds to wild-type LRP10, reducing its levels and affecting α-synuclein distribution [3].

In summary, Lrp10 is a key regulator in CD8 T-cell homeostasis and anti-tumor immunity, likely through its suppression of IL7R. In neurodegenerative diseases, especially those related to Lewy bodies, Lrp10 may play a role in disease pathogenesis through its involvement in vesicle trafficking and interaction with proteins like α-synuclein. Mouse models, especially those with Lrp10 loss-of-function mutations, have been crucial in uncovering these functions and their implications in disease [1,2,3].

References:
1. Russell, Jamie, Chen, Luming, Liu, Aijie, Beutler, Bruce, Nair-Gill, Evan. 2024. Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. In EMBO reports, 25, 3601-3626. doi:10.1038/s44319-024-00191-w. https://pubmed.ncbi.nlm.nih.gov/38956225/
2. Grochowska, Martyna M, Carreras Mascaro, Ana, Boumeester, Valerie, Bonifati, Vincenzo, Mandemakers, Wim. 2021. LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. In Acta neuropathologica, 142, 117-137. doi:10.1007/s00401-021-02313-3. https://pubmed.ncbi.nlm.nih.gov/33913039/
3. Carreras Mascaro, Ana, Grochowska, Martyna M, Boumeester, Valerie, Bonifati, Vincenzo, Mandemakers, Wim. 2024. LRP10 and α-synuclein transmission in Lewy body diseases. In Cellular and molecular life sciences : CMLS, 81, 75. doi:10.1007/s00018-024-05135-0. https://pubmed.ncbi.nlm.nih.gov/38315424/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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