C57BL/6JCya-Cxcl16em1flox/Cya
Common Name
Cxcl16-flox
Product ID
S-CKO-12878
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-66102-Cxcl16-B6J-VA
When using this mouse strain in a publication, please cite “Cxcl16-flox Mouse (Catalog S-CKO-12878) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cxcl16-flox
Strain ID
CKOCMP-66102-Cxcl16-B6J-VA
Gene Name
Product ID
S-CKO-12878
Gene Alias
0910001K24Rik, CXCL16v1, CXCL16v2, SR-PSOX, Zmynd15, b2b498Clo
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000019064
NCBI RefSeq
NM_023158
Target Region
Exon 4~5
Size of Effective Region
~1.2 kb
Overview of Gene Research
CXCL16, also known as C-X-C motif ligand 16, is a chemotactic cytokine belonging to the α -chemokine subfamily. It binds to the chemokine receptor CXCR6, a G protein -coupled receptor with 7 transmembrane domains. The CXCR6/CXCL16 axis is involved in various biological processes, regulating inflammation, tissue injury, and fibrosis. It plays a significant role in the pathogenesis of numerous diseases, including cancer, autoimmune diseases, fibrotic diseases, and atherosclerosis [1,2,4,5].
Deletion of Cxcl16 in non -obese diabetic (NOD) mice suppressed the development of autoimmune diabetes. Mechanistically, Cxcl16 deficiency impaired clearance of oxidized low -density lipoproteins (OxLDL) by islet macrophages, leading to OxLDL accumulation in pancreatic islets and a reduction in intra -islet transitory (Texint) CD8+ T cells, which are vulnerable to oxidative stress and ferroptosis [3].
In conclusion, CXCL16 is a crucial chemokine involved in multiple biological processes and disease conditions. The Cxcl16 -knockout mouse model has revealed its role in autoimmune diabetes, highlighting its significance in understanding the pathogenesis of this disease and potentially providing new therapeutic targets for treatment.
References：
1. Korbecki, Jan, Bajdak-Rusinek, Karolina, Kupnicka, Patrycja, Chlubek, Dariusz, Baranowska-Bosiacka, Irena. 2021. The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. In International journal of molecular sciences, 22, . doi:10.3390/ijms22073490. https://pubmed.ncbi.nlm.nih.gov/33800554/
2. Bao, Nandi, Fu, Bo, Zhong, Xiaoling, Xu, Shiping, Li, Tingting. 2023. Role of the CXCR6/CXCL16 axis in autoimmune diseases. In International immunopharmacology, 121, 110530. doi:10.1016/j.intimp.2023.110530. https://pubmed.ncbi.nlm.nih.gov/37348231/
3. Srivastava, Neetu, Hu, Hao, Peterson, Orion J, Unanue, Emil R, Wan, Xiaoxiao. 2024. CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity. In Immunity, 57, 1629-1647.e8. doi:10.1016/j.immuni.2024.04.017. https://pubmed.ncbi.nlm.nih.gov/38754432/
4. Wang, Fang-Tao, Wu, Tian-Qi, Lin, Yin, Yin, Lu, Chen, Chun-Qiu. 2024. The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease. In International immunopharmacology, 132, 112015. doi:10.1016/j.intimp.2024.112015. https://pubmed.ncbi.nlm.nih.gov/38608478/
5. Sheikine, Yuri, Sirsjö, Allan. 2008. CXCL16/SR-PSOX--a friend or a foe in atherosclerosis? In Atherosclerosis, 197, 487-95. doi:10.1016/j.atherosclerosis.2007.11.034. https://pubmed.ncbi.nlm.nih.gov/18191863/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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