C57BL/6JCya-Sec11cem1flox/Cya
Common Name:
Sec11c-flox
Product ID:
S-CKO-12995
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Sec11c-flox
Strain ID
CKOCMP-66286-Sec11c-B6J-VA
Gene Name
Product ID
S-CKO-12995
Gene Alias
1810029G24Rik; Sec11l3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sec11cem1flox/Cya mice (Catalog S-CKO-12995) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025394
NCBI RefSeq
NM_025468
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Sec11c is a gene encoding a subunit related to the signal peptidase complex (SPC) in the endoplasmic reticulum (ER). SPC is essential for removing signal peptides from secretory pre-proteins, and Sec11c may play a role in this process, though its exact function within the complex is yet to be fully elucidated. It is also associated with various biological processes and diseases [1].
In lung adenocarcinoma, Sec11c is part of a 6-gene prognostic risk score model related to T-cell-mediated tumor killing. This model can screen prognosis of patients and those sensitive to immunotherapy [2].
In parathyroid adenoma, studies suggest that Sec11c may be an important factor contributing to its development, as its differential expression is noted in parathyroid adenomas compared to normal tissues [3,5].
In pigs, potential deleterious variation in the Sec11c gene was identified through analysis of homozygous-by-descent segments, and it was also associated with growth-related traits and lipid biosynthesis and fatty acid composition [4,6,7].
In colon cancer cells, exposure to PSP205 led to transcriptional upregulation of Sec11c, which is implicated in ER stress [8].
In summary, Sec11c appears to be involved in multiple biological processes and disease conditions. Its role in lung adenocarcinoma prognosis, parathyroid adenoma development, and pig-related traits provides insights into disease mechanisms and potential applications in different fields. The study of Sec11c helps in understanding the underlying molecular mechanisms related to these biological events and diseases.
References:
1. Liaci, A Manuel, Steigenberger, Barbara, Telles de Souza, Paulo Cesar, Scheltema, Richard A, Förster, Friedrich. 2021. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. In Molecular cell, 81, 3934-3948.e11. doi:10.1016/j.molcel.2021.07.031. https://pubmed.ncbi.nlm.nih.gov/34388369/
2. Bi, Lei, Ai, Cheng, Zhang, Hong, Xiong, Jing, Lv, Zhongzhu. . Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma. In Autoimmunity, 56, 2250097. doi:10.1080/08916934.2023.2250097. https://pubmed.ncbi.nlm.nih.gov/37624966/
3. Kim, Sang Wan. 2022. Gene expression profiles in parathyroid adenoma and normal parathyroid tissue. In Vitamins and hormones, 120, 289-304. doi:10.1016/bs.vh.2022.04.003. https://pubmed.ncbi.nlm.nih.gov/35953114/
4. Bakoev, Siroj, Kolosov, Anatoly, Bakoev, Faridun, Koshkina, Olga, Getmantseva, Lyubov. 2021. Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia. In Life (Basel, Switzerland), 11, . doi:10.3390/life11080861. https://pubmed.ncbi.nlm.nih.gov/34440604/
5. Chai, Young Jun, Chae, Heejoon, Kim, Kwangsoo, Lee, Kyu Eun, Kim, Sang Wan. 2019. Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue. In Journal of clinical medicine, 8, . doi:10.3390/jcm8030297. https://pubmed.ncbi.nlm.nih.gov/30832348/
6. Tang, Zhenshuang, Xu, Jingya, Yin, Lilin, Zhao, Shuhong, Liu, Xiaolei. 2019. Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs. In Frontiers in genetics, 10, 302. doi:10.3389/fgene.2019.00302. https://pubmed.ncbi.nlm.nih.gov/31024621/
7. Ma, Fuping, Zou, Quan, Zhao, Xitong, Ding, Xiangdong, Wang, Chuduan. 2025. Multi-omics integration reveals the regulatory mechanisms of APC and CREB5 genes in lipid biosynthesis and fatty acid composition in pigs. In Food chemistry, 482, 143999. doi:10.1016/j.foodchem.2025.143999. https://pubmed.ncbi.nlm.nih.gov/40187300/
8. Samanta, Soma, Roy, Joyeeta, Debnath, Bikash, Ljungman, Mats, Neamati, Nouri. 2025. PSP205, a Novel Phenyl Sulfonyl Piperidine, Induces Apoptotic Cell Death in Colon Cancer by Modulating Coat Protein Complex-Mediated Vesicle Trafficking. In ACS pharmacology & translational science, 8, 1072-1086. doi:10.1021/acsptsci.4c00617. https://pubmed.ncbi.nlm.nih.gov/40242573/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen