C57BL/6JCya-Mrps15em1flox/Cya
Common Name:
Mrps15-flox
Product ID:
S-CKO-13066
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Mrps15-flox
Strain ID
CKOCMP-66407-Mrps15-B6J-VA
Gene Name
Product ID
S-CKO-13066
Gene Alias
1500003E24Rik; 2410002B11Rik; Mprs15
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrps15em1flox/Cya mice (Catalog S-CKO-13066) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000030675
NCBI RefSeq
NM_025544
Target Region
Exon 3~4
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Mrps15, a mitochondrial ribosomal protein gene, is an essential component for the structural and functional integrity of the mitoribosome complex. Mammalian mitoribosomes have acquired new Mrp genes during evolution, and Mrps15 is among them. Mitoribosomes are crucial for mitochondrial translation of protein components of the OXPHOS complex, thus Mrps15 is likely involved in maintaining mitochondrial function and energy metabolism [1,5].
In stressed cardiomyocytes, MRPS15 translocates to cytosolic ribosomes and regulates internal ribosome entry site (IRES)-dependent translation, playing a role in controlling gene expression under stress conditions [2].
In hepatocellular carcinoma, a prognostic model integrating MRPS15 and other genes shows better clinical net benefit, indicating its potential in predicting prognosis [3].
In lung adenocarcinoma, MRPS15 is among hub genes influenced by smoke-induced differential DNA methylation, enriching in RNA processing, ribosome biogenesis, and mitochondrial translation, crucial for cancer progression [4].
In collagen VI-related dystrophies, MRPS15 is identified as a potential hub gene, providing insights into disease-related pathophysiological pathways [6].
In summary, Mrps15 is vital for mitoribosome function and is involved in various biological processes and disease conditions. Its role in stress-related translation regulation, cancer prognosis, and rare muscle disorders highlights its significance in understanding disease mechanisms, offering potential targets for therapeutic interventions.
References：
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. David, Florian, Roussel, Emilie, Froment, Carine, Garmy-Susini, Barbara, Prats, Anne-Catherine. 2024. Mitochondrial Ribosomal Protein MRPS15 Is a Component of Cytosolic Ribosomes and Regulates Translation in Stressed Cardiomyocytes. In International journal of molecular sciences, 25, . doi:10.3390/ijms25063250. https://pubmed.ncbi.nlm.nih.gov/38542224/
3. Zhao, Jin-Wei, Zhao, Wei-Yi, Cui, Xin-Hua, Shi, Jia-Cheng, Yu, Lu. 2023. The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 496-514. doi:10.1007/s12094-023-03269-4. https://pubmed.ncbi.nlm.nih.gov/37407805/
4. Mukherjee, Arnab, Boonbangyang, Manon, K S, Mukunthan. 2025. Unraveling the intricate molecular landscape and potential biomarkers in lung adenocarcinoma through integrative epigenomic and transcriptomic profiling. In Scientific reports, 15, 9154. doi:10.1038/s41598-025-93769-w. https://pubmed.ncbi.nlm.nih.gov/40097569/
5. Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Howell, Anthony, Lisanti, Michael P. 2012. Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. In Cell cycle (Georgetown, Tex.), 11, 4390-401. doi:10.4161/cc.22777. https://pubmed.ncbi.nlm.nih.gov/23172368/
6. Ceyhan, Atakan Burak, Kaynar, Ali, Altay, Ozlem, Turkez, Hasan, Mardinoglu, Adil. 2024. Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention. In Biomolecules, 14, . doi:10.3390/biom14111376. https://pubmed.ncbi.nlm.nih.gov/39595553/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen