C57BL/6JCya-Pspc1em1flox/Cya
Common Name:
Pspc1-flox
Product ID:
S-CKO-13216
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Pspc1-flox
Strain ID
CKOCMP-66645-Pspc1-B6J-VA
Gene Name
Product ID
S-CKO-13216
Gene Alias
5730470C09Rik; PSP1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
14
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pspc1em1flox/Cya mice (Catalog S-CKO-13216) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022507
NCBI RefSeq
NM_025682
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
PSPC1, known as Paraspeckle component 1, is involved in multiple biological processes. It plays a role in nucleocytoplasmic shuttling, a process dysregulated in cancers and emerging as a cancer hallmark [1,2]. It also has implications in epigenetic regulation as it interacts with proteins like KDM5C in prostate cancer [3].
In acute myeloid leukemia (AML), PSPC1 is aberrantly overexpressed. Using human AML cells and mouse models, loss of PSPC1 in AML cells induced robust differentiation, suppressed proliferation, and abolished leukemogenesis, showing its critical role in maintaining leukemic characteristics [4]. In hepatocellular carcinoma (HCC), PSPC1 is a contextual determinant of the TGF-β prometastatic switch and PTK6/β-catenin reciprocal oncogenic nucleocytoplasmic shuttling. The PSPC1 C-terminal 131 polypeptide (PSPC1-CT131) targeting PSPC1 and PTK6 exhibited synergistic tumor-suppressive effects in HCC cells and mouse models [1].
In conclusion, PSPC1 has diverse functions in biological processes, especially in the context of cancer. Mouse models, such as those used in AML and HCC studies, have revealed its oncogenic roles, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Lang, Yaw-Dong, Jou, Yuh-Shan. 2021. PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. In Journal of biomedical science, 28, 57. doi:10.1186/s12929-021-00753-3. https://pubmed.ncbi.nlm.nih.gov/34340703/
2. Lang, Yaw-Dong, Jou, Yuh-Shan. 2020. PSPC1: a contextual determinant of tumor progression. In Molecular & cellular oncology, 7, 1721253. doi:10.1080/23723556.2020.1721253. https://pubmed.ncbi.nlm.nih.gov/32158931/
3. Lemster, Anna-Lena, Weingart, Anika, Bottner, Justus, Offermann, Anne, Kirfel, Jutta. 2023. Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer. In Human pathology, 138, 1-11. doi:10.1016/j.humpath.2023.05.007. https://pubmed.ncbi.nlm.nih.gov/37209920/
4. Hong, Juyeong, Sui, Pinpin, Li, Ying, Wang, Jianlong, Xu, Mingjiang. 2025. PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. In Cell stem cell, 32, 463-478.e6. doi:10.1016/j.stem.2025.01.010. https://pubmed.ncbi.nlm.nih.gov/39954676/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen