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C57BL/6JCya-Lrrk2em1flox/Cya
Common Name:
Lrrk2-flox
Product ID:
S-CKO-13268
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lrrk2-flox
Strain ID
CKOCMP-66725-Lrrk2-B6J-VA
Gene Name
Lrrk2
Product ID
S-CKO-13268
Gene Alias
4921513O20Rik; 9330188B09Rik; D630001M17Rik; Gm927; cI-46
Background
C57BL/6JCya
NCBI ID
66725
Modification
Conditional knockout
Chromosome
15
Phenotype
MGI:1913975
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrrk2em1flox/Cya mice (Catalog S-CKO-13268) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000060642
NCBI RefSeq
NM_025730
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
LRRK2, or Leucine-rich repeat kinase 2, is a complex protein with a GTPase and a kinase domain. It is involved in multiple cellular processes such as cytoskeletal dynamics, endolysosomal pathway, membrane and vesicle trafficking, and is linked to pathways like autophagy and lysosome biology [2,3,5,7]. Mutations in LRRK2 are the most common cause of familial Parkinson's disease (PD) and are also associated with a significant proportion of sporadic PD cases, making genetic models crucial for its study [1,4].

Point mutations in LRRK2-driven PD models have shown that LRRK2 has key functions in the endolysosomal system and is regulated by and interacts with Rab GTPases [1]. It is recruited to and activated at stressed or damaged lysosomes through interaction with GABARAP [6]. Additionally, its interaction with the cytoskeleton is relevant to protein degradation and inhibitor therapies [1]. LRRK2's interaction with other PD-driving genes may highlight broader disrupted cellular pathways in PD [1].

In conclusion, LRRK2 plays essential roles in multiple cellular pathways, especially those related to endolysosomal function and membrane trafficking. Studies using LRRK2-related genetic models, such as those with point mutations relevant to PD, have significantly contributed to understanding its role in PD pathogenesis, providing a basis for potential therapeutic strategies targeting this gene in PD treatment.

References:
1. Usmani, Ahsan, Shavarebi, Farbod, Hiniker, Annie. 2021. The Cell Biology of LRRK2 in Parkinson's Disease. In Molecular and cellular biology, 41, . doi:10.1128/MCB.00660-20. https://pubmed.ncbi.nlm.nih.gov/33526455/
2. Zhang, Xiaojuan, Kortholt, Arjan. 2023. LRRK2 Structure-Based Activation Mechanism and Pathogenesis. In Biomolecules, 13, . doi:10.3390/biom13040612. https://pubmed.ncbi.nlm.nih.gov/37189360/
3. Bonet-Ponce, Luis, Cookson, Mark R. 2021. LRRK2 recruitment, activity, and function in organelles. In The FEBS journal, 289, 6871-6890. doi:10.1111/febs.16099. https://pubmed.ncbi.nlm.nih.gov/34196120/
4. Xiong, Yulan, Yu, Jianzhong. 2024. LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting. In Trends in molecular medicine, 30, 982-996. doi:10.1016/j.molmed.2024.07.003. https://pubmed.ncbi.nlm.nih.gov/39153957/
5. Iannotta, Lucia, Greggio, Elisa. . LRRK2 signaling in neurodegeneration: two decades of progress. In Essays in biochemistry, 65, 859-872. doi:10.1042/EBC20210013. https://pubmed.ncbi.nlm.nih.gov/34897411/
6. Bentley-DeSousa, Amanda, Clegg, Devin, Ferguson, Shawn M. 2025. LRRK2, lysosome damage, and Parkinson's disease. In Current opinion in cell biology, 93, 102482. doi:10.1016/j.ceb.2025.102482. https://pubmed.ncbi.nlm.nih.gov/39983584/
7. Piccoli, Giovanni, Volta, Mattia. . LRRK2 along the Golgi and lysosome connection: a jamming situation. In Biochemical Society transactions, 49, 2063-2072. doi:10.1042/BST20201146. https://pubmed.ncbi.nlm.nih.gov/34495322/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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