C57BL/6JCya-Dusp26em1flox/Cya
Common Name:
Dusp26-flox
Product ID:
S-CKO-13412
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Dusp26-flox
Strain ID
CKOCMP-66959-Dusp26-B6J-VA
Gene Name
Product ID
S-CKO-13412
Gene Alias
2310043K02Rik; Skrp3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dusp26em1flox/Cya mice (Catalog S-CKO-13412) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000036631
NCBI RefSeq
NM_025869
Target Region
Exon 3~4
Size of Effective Region
~3.6 kb
Detailed Document
Overview of Gene Research
Dusp26, also known as neuroendocrine-associated phosphatase (NEAP), is an atypical dual-specificity phosphatase. It plays a role in regulating intracellular signaling pathways, especially those related to MAP kinases. It has been implicated in a wide range of physiological processes, including cell growth, differentiation, and neuronal development [2,6].
In disease-related research, gene knockout models have provided insights. In ApoE-/-mice fed a high-cholesterol diet, Dusp26 silencing ameliorated aortic valve calcification, reducing valve thickness, calcium deposition, and osteogenic marker levels [1]. In diabetic cardiomyopathy, Dusp26 expression was downregulated in diabetic db/db mice. Overexpression in these mice improved cardiac function, mitochondrial function, and reduced fibrosis and hypertrophy [3]. In diabetic nephropathy, Dusp26 deficiency in mice accelerated renal injury, fibrosis, and oxidative stress [5]. In glioblastoma cells, decreased Dusp26 expression promoted malignant behavior [4]. In prostate cancer cells, overexpression of Dusp26 inhibited cell proliferation, migration, and invasion [7].
In conclusion, Dusp26 is crucial in multiple biological processes and disease conditions. Gene knockout and overexpression models in mice have revealed its role in aortic valve calcification, diabetic cardiomyopathy, diabetic nephropathy, glioblastoma, and prostate cancer. Understanding Dusp26's functions can potentially lead to new therapeutic strategies for these diseases.
References:
1. Wang, Yongjun, Han, Dong, Zhou, Tingwen, Cao, Feng, Dong, Nianguo. . DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells. In European heart journal, 42, 2935-2951. doi:10.1093/eurheartj/ehab316. https://pubmed.ncbi.nlm.nih.gov/34179958/
2. Thompson, Elliott M, Stoker, Andrew W. 2021. A Review of DUSP26: Structure, Regulation and Relevance in Human Disease. In International journal of molecular sciences, 22, . doi:10.3390/ijms22020776. https://pubmed.ncbi.nlm.nih.gov/33466673/
3. Liu, Chong, Xu, Xiangli, Sun, Guiming, Sun, Ping, Tian, Jiawei. 2024. Targeting DUSP26 to drive cardiac mitochondrial dynamics via FAK-ERK signaling in diabetic cardiomyopathy. In Free radical biology & medicine, 225, 856-870. doi:10.1016/j.freeradbiomed.2024.11.006. https://pubmed.ncbi.nlm.nih.gov/39510451/
4. Chen, Jiajia, Zeng, Yuecan, Wu, Rong, Jiang, Min, Teng, Hao. 2021. Decreased DUSP26 Expression Promotes Malignant Behavior in Glioblastoma Cells via Deregulation of MAPK and Akt Signaling Pathway. In Frontiers in oncology, 11, 622826. doi:10.3389/fonc.2021.622826. https://pubmed.ncbi.nlm.nih.gov/33718185/
5. Huang, Feng, Sheng, Xu-Xiang, Zhang, Hong-Juan. 2019. DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS. In Biochemical and biophysical research communications, 515, 410-416. doi:10.1016/j.bbrc.2019.05.032. https://pubmed.ncbi.nlm.nih.gov/31155289/
6. Yang, Chi-Hwa, Yeh, Yu-Jung, Wang, Jiz-Yuh, Yuh, Chiou-Hwa, Chen, Yi-Rong. 2017. NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. In Scientific reports, 7, 5241. doi:10.1038/s41598-017-05584-7. https://pubmed.ncbi.nlm.nih.gov/28701747/
7. Huang, Ruo-Hui, Zeng, Qing-Ming, Jiang, Bo, Zhang, Guo-Xi, Zou, Xiao-Feng. 2024. Overexpression of DUSP26 gene suppressed the proliferation, migration, and invasion of human prostate cancer cells. In Experimental cell research, 442, 114231. doi:10.1016/j.yexcr.2024.114231. https://pubmed.ncbi.nlm.nih.gov/39222869/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen