C57BL/6JCya-Mboat2em1flox/Cya
Common Name:
Mboat2-flox
Product ID:
S-CKO-13570
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Mboat2-flox
Strain ID
CKOCMP-67216-Mboat2-B6J-VA
Gene Name
Product ID
S-CKO-13570
Gene Alias
2810049G06Rik; LPCAT4; Moact2; Oact2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mboat2em1flox/Cya mice (Catalog S-CKO-13570) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000110942
NCBI RefSeq
NM_026037
Target Region
Exon 7~8
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Mboat2, short for membrane bound O-acyltransferase domain containing 2, is a phospholipid-modifying enzyme. It plays a crucial role in iron homeostasis by inhibiting iron sequestration, preventing iron-induced cell death through remodeling the phospholipid composition of cell membranes via phospholipid metabolism [5]. It is also transcriptionally upregulated by sex hormone receptors, like the androgen receptor [2].
In multiple cancer types, Mboat2 shows significant associations. In pancreatic cancer, its overexpression accelerates cell proliferation and migration, enhances CDK2 and CCNA2 expression for cell cycle progression, and reduces CD8+ T-cell infiltration [3]. In intrahepatic cholangiocarcinoma (ICC), a lipid-metabolism related circRNA, circMBOAT2, stabilizes PTBP1 to facilitate FASN mRNA cytoplasmic export, promoting ICC progression and lipid metabolism reprogramming [1]. In endometrial cancer, a five-gene metabolism-related risk signature including Mboat2 can predict prognosis and immune infiltration [4]. Also, MBOAT2 may act as a ferroptosis suppressor independent of GPX4 or FSP1 by remodeling the cellular phospholipid profile [2].
In conclusion, Mboat2 is involved in various biological processes, especially in lipid metabolism and iron homeostasis. Its dysregulation is closely related to the development of multiple cancers, highlighting its potential as a prognostic biomarker and a target for immunotherapy in malignancies. Research on Mboat2, including through gene knockout models (if applicable in the future), will further enhance our understanding of its role in disease mechanisms.
References:
1. Yu, Xiaopeng, Tong, Huanjun, Chen, Jialu, Wang, Shouhua, Tang, Zhaohui. 2023. CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. In Cell death & disease, 14, 20. doi:10.1038/s41419-022-05540-y. https://pubmed.ncbi.nlm.nih.gov/36635270/
2. Liang, Deguang, Feng, Yan, Zandkarimi, Fereshteh, Stockwell, Brent R, Jiang, Xuejun. 2023. Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. In Cell, 186, 2748-2764.e22. doi:10.1016/j.cell.2023.05.003. https://pubmed.ncbi.nlm.nih.gov/37267948/
3. Li, Zhenchong, Zhuang, Hongkai, Chen, Xinming, Zhang, Chuanzhao, Hou, Baohua. 2022. Identification of MBOAT2 as an Unfavorable Biomarker Correlated with KRAS Activation and Reduced CD8+ T-Cell Infiltration in Pancreatic Cancer. In Journal of oncology, 2022, 4269733. doi:10.1155/2022/4269733. https://pubmed.ncbi.nlm.nih.gov/35571489/
4. Huang, Huaqing, Cai, Xintong, Lin, Jiexiang, Liu, Bin, Lin, Jie. 2023. A novel five-gene metabolism-related risk signature for predicting prognosis and immune infiltration in endometrial cancer: A TCGA data mining. In Computers in biology and medicine, 155, 106632. doi:10.1016/j.compbiomed.2023.106632. https://pubmed.ncbi.nlm.nih.gov/36805217/
5. Xie, Yuhan, Zhang, Shichao, Wu, Yu, Chen, Xiuju, Chen, Bing. 2025. Pan-cancer analysis predicts MBOAT2 as a potential new ferroptosis related gene immune checkpoint. In Discover oncology, 16, 322. doi:10.1007/s12672-025-02078-1. https://pubmed.ncbi.nlm.nih.gov/40088361/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen