C57BL/6JCya-Cxxc5em1flox/Cya
Common Name
Cxxc5-flox
Product ID
S-CKO-13663
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-67393-Cxxc5-B6J-VA
When using this mouse strain in a publication, please cite “Cxxc5-flox Mouse (Catalog S-CKO-13663) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cxxc5-flox
Strain ID
CKOCMP-67393-Cxxc5-B6J-VA
Gene Name
Product ID
S-CKO-13663
Gene Alias
4930415K17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 18
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000060722
NCBI RefSeq
NM_133687.3
Target Region
Exon 2
Size of Effective Region
~2.0 kb
Overview of Gene Research
CXXC5, a member of the CXXC-type zinc-finger protein family, plays a pivotal role in epigenetic regulation. It binds to unmethylated CpG islands in gene promoters via its CXXC domain, acting as a transcription factor and epigenetic factor without a catalytic domain. CXXC5 is an important signal integrator, regulated by multiple signaling pathways and capable of regulating TGF-β, Wnt, ATM-p53 and other pathways, crucial for embryonic development and adult tissue homeostasis [1].
CXXC5 knockout (KO) mouse models have revealed its diverse functions. In hair-related studies, Cxxc5 KO mice displayed accelerated hair regrowth, indicating CXXC5 is a negative regulator of the Wnt/β-catenin pathway in hair regrowth [2]. In metabolic disease research, Cxxc5-/-mice fed a high-fat diet were resistant to metabolic dysregulation, suggesting that CXXC5 overexpression in visceral adipose tissues may contribute to obesity-related diabetes [3].
In conclusion, CXXC5 is essential for multiple biological processes, regulating cell proliferation, differentiation, and apoptosis. Model-based research, especially KO mouse models, has shown its significance in diseases such as tumorigenesis, hair loss, and obesity-related metabolic diseases. Understanding CXXC5 provides insights into disease mechanisms and potential therapeutic targets.
References：
1. Xiong, Xiangyang, Tu, Shuo, Wang, Jianbin, Luo, Shiwen, Yan, Xiaohua. 2018. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling. In Journal of cellular and molecular medicine, 23, 740-749. doi:10.1111/jcmm.14046. https://pubmed.ncbi.nlm.nih.gov/30479059/
2. Lee, Soung-Hoon, Seo, Seol Hwa, Lee, Dong-Hwan, Lee, Won-Soo, Choi, Kang-Yell. 2017. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. In The Journal of investigative dermatology, 137, 2260-2269. doi:10.1016/j.jid.2017.04.038. https://pubmed.ncbi.nlm.nih.gov/28595998/
3. Seo, Seol Hwa, Kim, Eunhwan, Lee, Soung-Hoon, Seong, Je Kyung, Choi, Kang-Yell. . Inhibition of CXXC5 function reverses obesity-related metabolic diseases. In Clinical and translational medicine, 12, e742. doi:10.1002/ctm2.742. https://pubmed.ncbi.nlm.nih.gov/35384342/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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