C57BL/6JCya-Fgfr1op2em1flox/Cya
Common Name:
Fgfr1op2-flox
Product ID:
S-CKO-13742
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fgfr1op2-flox
Strain ID
CKOCMP-67529-Fgfr1op2-B6J-VA
Gene Name
Product ID
S-CKO-13742
Gene Alias
1500031J01Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fgfr1op2em1flox/Cya mice (Catalog S-CKO-13742) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111663
NCBI RefSeq
NM_026218
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Fgfr1op2, also known as wound inducible transcript-3.0 (wit3.0), is a gene encoding a protein with coiled-coil domains [5]. It is associated with cytoskeleton networks, and may play roles in cell motility, wound closure, and is involved in certain genetic associations related to jawbone atrophy [3,4].
In a mouse model, the fusion gene FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma, suggesting its oncogenic potential [1]. In skeletal muscle, SRSF1 is crucial for regulating the splicing of Fgfr1op2. Disrupting SRSF1 in myoblasts leads to dysregulated splicing of Fgfr1op2, multipolar spindle formation, and cellular senescence, highlighting the importance of proper Fgfr1op2 splicing in muscle cell function [2].
In conclusion, Fgfr1op2 is involved in diverse biological processes such as cell-motility-related wound closure and has implications in muscle cell homeostasis. The FGFR1OP2-FGFR1 fusion gene in mouse models shows its significance in leukemia and lymphoma development, emphasizing its role in understanding these disease mechanisms [1,2,3,4].
References：
1. Qin, Haiyan, Wu, Qing, Cowell, John K, Ren, Mingqiang. 2015. FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model. In Haematologica, 101, e91-4. doi:10.3324/haematol.2015.137695. https://pubmed.ncbi.nlm.nih.gov/26589915/
2. Wang, Zhenzhen, Peng, Qian, Zhang, Zhige, Han, Jun, Feng, Ying. 2024. SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration. In Journal of cachexia, sarcopenia and muscle, 15, 2629-2641. doi:10.1002/jcsm.13607. https://pubmed.ncbi.nlm.nih.gov/39381961/
3. Lin, Audrey, Hokugo, Akishige, Choi, Jae, Nishimura, Ichiro. 2009. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. In The American journal of pathology, 176, 108-21. doi:10.2353/ajpath.2010.090256. https://pubmed.ncbi.nlm.nih.gov/19959814/
4. Suwanwela, Jaijam, Lee, Jaehoon, Lin, Audrey, Garrett, Neal R, Nishimura, Ichiro. 2011. A genetic association study of single nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible. In PloS one, 6, e16204. doi:10.1371/journal.pone.0016204. https://pubmed.ncbi.nlm.nih.gov/21283824/
5. Grand, Effie K, Grand, Francis H, Chase, Andrew J, Oscier, David G, Cross, Nicholas C P. . Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. In Genes, chromosomes & cancer, 40, 78-83. doi:. https://pubmed.ncbi.nlm.nih.gov/15034873/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen