Lce1f is a gene within the Late Cornified Envelope Group I (LCE1) gene cluster, which encodes well-conserved stratum-corneum proteins. It has been identified as a novel downstream target of the tumor suppressor gene p53. Lce1f may regulate the activity of protein arginine methyltransferase 5 (PRMT5), potentially playing a role in tumor suppression [2]. It is also involved in pathways related to DNA damage response, as its expression was found to increase with UVC radiation dose in human lymphocytes, along with its co-expressed gene LOC338799 and others, suggesting a link to the p53 signaling pathway [3].

In a bioinformatics study on the cross-talk between periodontitis and hypothyroidism, Lce1f was among the top 10 genes with the most connections among the overlapping differentially expressed genes. This indicates its potential importance in the genetic cross-talk between these two conditions, although the exact role via gene knockout or conditional knockout models was not detailed in the provided references [1].

In conclusion, Lce1f appears to be involved in important biological functions such as tumor suppression through regulation of PRMT5 activity and in DNA damage response. Its role in the genetic cross-talk between periodontitis and hypothyroidism suggests its significance in understanding the relationship between these diseases. Further in vivo studies using gene knockout or conditional knockout mouse models could potentially provide more insights into its specific functions in these disease areas.