C57BL/6JCya-Slc39a13em1flox/Cya
Common Name:
Slc39a13-flox
Product ID:
S-CKO-14169
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc39a13-flox
Strain ID
CKOCMP-68427-Slc39a13-B6J-VA
Gene Name
Product ID
S-CKO-14169
Gene Alias
1100001L14Rik; ZIP-13; ZIP13
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc39a13em1flox/Cya mice (Catalog S-CKO-14169) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111436
NCBI RefSeq
NM_001290765
Target Region
Exon 2
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Slc39a13, also known as ZIP13, is a zinc transporter that has been found to be involved in multiple crucial biological functions. It plays a role in iron transport and homeostasis, as well as in the BMP/TGF-beta signaling pathways, which are important for connective tissue development [1,5].
In gene knockout studies, Zip13-knockout male mice show iron deposition in several tissues, indicating that ZIP13 is crucial for iron homeostasis, possibly by shunting iron from the cytosol to the ER/Golgi hub [1]. Zip13-knockout mice also exhibit abnormalities in the aortic wall and cornea, such as changes in the number and morphology of elastic and cellular components in the aorta, and various morphometric differences in the cornea [2,4]. These phenotypes suggest the importance of Slc39a13 in maintaining the integrity of connective tissues. Additionally, down-regulation of ZIP13 in mouse hearts leads to activation of CaMKII at reperfusion, exacerbating myocardial ischemia/reperfusion injury [3].
In conclusion, Slc39a13 is essential for iron homeostasis and connective tissue development. The study of Slc39a13 knockout mouse models has provided insights into its role in diseases related to iron metabolism disorders, connective tissue dysfunctions like Ehlers-Danlos syndrome, and myocardial ischemia/reperfusion injury. Understanding the functions of Slc39a13 can potentially lead to new strategies for treating these diseases.
References:
1. Li, Huihui, Cui, Yanmei, Hu, Yule, Sun, Fei, Zhou, Bing. 2024. Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments. In Nature communications, 15, 10838. doi:10.1038/s41467-024-55149-2. https://pubmed.ncbi.nlm.nih.gov/39738060/
2. Hirose, Takuya, Shimazaki, Takamasa, Takahashi, Naoki, Tangkawattana, Prasarn, Takehana, Kazushige. 2019. Morphometric analysis of thoracic aorta in Slc39a13/Zip13-KO mice. In Cell and tissue research, 376, 137-141. doi:10.1007/s00441-018-2977-9. https://pubmed.ncbi.nlm.nih.gov/30610452/
3. Wang, Jie, Cheng, Xinxin, Zhao, Huanhuan, Yang, Qing, Xu, Zhelong. 2020. Downregulation of the zinc transporter SLC39A13 (ZIP13) is responsible for the activation of CaMKII at reperfusion and leads to myocardial ischemia/reperfusion injury in mouse hearts. In Journal of molecular and cellular cardiology, 152, 69-79. doi:10.1016/j.yjmcc.2020.12.002. https://pubmed.ncbi.nlm.nih.gov/33307093/
4. Hirose, Takuya, Suzuki, Ippei, Takahashi, Naoki, Tangkawattana, Prasarn, Takehana, Kazushige. 2018. Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice. In The Journal of veterinary medical science, 80, 814-818. doi:10.1292/jvms.18-0019. https://pubmed.ncbi.nlm.nih.gov/29563392/
5. Fukada, Toshiyuki, Civic, Natacha, Furuichi, Tatsuya, Superti-Furga, Andrea, Hirano, Toshio. 2008. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. In PloS one, 3, e3642. doi:10.1371/journal.pone.0003642. https://pubmed.ncbi.nlm.nih.gov/18985159/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen