C57BL/6JCya-Scgb3a1em1flox/Cya
Common Name:
Scgb3a1-flox
Product ID:
S-CKO-14252
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Scgb3a1-flox
Strain ID
CKOCMP-68662-Scgb3a1-B6J-VA
Gene Name
Product ID
S-CKO-14252
Gene Alias
HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Scgb3a1em1flox/Cya mice (Catalog S-CKO-14252) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000076006
NCBI RefSeq
NM_170727
Target Region
Exon 2~4
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Scgb3a1, also known as UGRP2, is a member of the secretoglobin gene super family. Secretoglobins are cytokine-like small molecular weight secreted proteins. Scgb3a1 may possess unique biological functions, potentially related to immunoregulatory functions as it is expressed in airway epithelium, and has been associated with antibacterial response, humoral immune response, and response to external stimuli [1,3,4]. It may also have tumor suppressor function [5].
In a study using Scgb3a1-null mice as negative controls, the lack of Scgb3a1 did not affect the expression of other Scgb genes or the development of pulmonary neuroepithelial bodies during embryogenesis [1]. In smoking-related lung cancer, the down-regulation of Scgb3a1 was observed, and high expression of it was associated with favorable prognosis [3]. In nasal polyposis, certain alleles of Scgb3a1 might have a protective effect [2].
In conclusion, Scgb3a1 has diverse biological functions, especially in airway-related immunoregulation and potentially in cancer prognosis. The use of Scgb3a1-null mouse models has provided insights into its non-redundant role in embryonic development and its implications in diseases such as lung cancer and nasal polyposis.
References：
1. Naizhen, Xu, Kido, Taketomo, Yokoyama, Shigetoshi, Linnoila, R Ilona, Kimura, Shioko. 2019. Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia. In The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 67, 453-463. doi:10.1369/0022155419829050. https://pubmed.ncbi.nlm.nih.gov/30768367/
2. Palalı, Mehmet, Murat Özcan, K, Ozdaş, Sibel, Ensari, Serdar, Dere, Hüseyin. 2014. Investigation of SCGB3A1 (UGRP2) gene arrays in patients with nasal polyposis. In European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 271, 3209-14. doi:10.1007/s00405-014-3020-8. https://pubmed.ncbi.nlm.nih.gov/24710847/
3. Liang, Chen, Pan, Wei, Zhou, Zhijun, Liu, Xiaomin. 2024. Identification of prognostic biomarkers of smoking-related lung cancer. In Journal of thoracic disease, 16, 1438-1449. doi:10.21037/jtd-23-1890. https://pubmed.ncbi.nlm.nih.gov/38505085/
4. Reynolds, Susan D, Reynolds, Paul R, Pryhuber, Gloria S, Finder, Jonathan D, Stripp, Barry R. 2002. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. In American journal of respiratory and critical care medicine, 166, 1498-509. doi:. https://pubmed.ncbi.nlm.nih.gov/12406855/
5. Tomita, Takeshi, Kimura, Shioko. 2008. Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression. In BMC molecular biology, 9, 5. doi:10.1186/1471-2199-9-5. https://pubmed.ncbi.nlm.nih.gov/18194566/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen