C57BL/6JCya-Snx15em1flox/Cya
Common Name
Snx15-flox
Product ID
S-CKO-14385
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-69024-Snx15-B6J-VA
When using this mouse strain in a publication, please cite “Snx15-flox Mouse (Catalog S-CKO-14385) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Snx15-flox
Strain ID
CKOCMP-69024-Snx15-B6J-VA
Gene Name
Product ID
S-CKO-14385
Gene Alias
1500032B08Rik, E130013C21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000025702
NCBI RefSeq
NM_026912
Target Region
Exon 2~3
Size of Effective Region
~2.3 kb
Overview of Gene Research
Snx15, a sorting nexin, is involved in protein trafficking. It contains a Phox-homology domain crucial for protein-protein interactions among sorting nexins and other partners [1]. It is known to regulate the endosomal network, participating in pathways like the endocytic recycling of proteins [3,4,5,6,7]. It may also be associated with Alzheimer's disease, as it can regulate the cell-surface recycling of amyloid-β precursor protein (APP) and Aβ generation [2].
In an acute promyelocytic leukemia (APL) case, a novel RARA-Snx15 fusion was detected due to RNA mis-splicing. The in-frame fusion RARA-Snx15L consisted mainly of Snx15 domains and was directly associated with Snx15 and itself. Further study is needed to evaluate its biological significance in APL [1]. In Alzheimer's disease research, overexpression and downregulation of Snx15 in mouse neurons and astrocytes were found to respectively reduce and promote Aβ production. Exogenous expression of human Snx15 in the hippocampal dentate gyrus of APPswe/PSEN1dE9 double-transgenic AD model mice could reduce Aβ pathology and improve short-term working memory [2].
In conclusion, Snx15 is significant in protein trafficking and endosomal recycling processes. Its study in mouse models has provided insights into its role in Alzheimer's disease and may potentially offer understanding in APL. These model-based studies help clarify Snx15's functions and its implications in disease, which could potentially guide future research and treatment strategies.
References：
1. Hirade, Kentaro, Kusumoto, Shigeru, Abe, Akihiro, Iida, Shinsuke, Yamamoto, Yukiya. 2022. A novel RARA-SNX15 fusion in PML-RARA-positive acute promyelocytic leukemia with t(11;17;15)(q13;q21.2;q24.1). In International journal of hematology, 116, 956-960. doi:10.1007/s12185-022-03421-w. https://pubmed.ncbi.nlm.nih.gov/35854096/
2. Feng, Tuancheng, Niu, Mengmeng, Ji, Chengxiang, Xu, Huaxi, Zhang, Yun-Wu. 2015. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. In Molecular neurobiology, 53, 3690-3701. doi:10.1007/s12035-015-9306-z. https://pubmed.ncbi.nlm.nih.gov/26115702/
3. Danson, Chris, Brown, Edward, Hemmings, Oliver J, Verkade, Paul, Cullen, Peter J. 2013. SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome. In Journal of cell science, 126, 4885-99. doi:10.1242/jcs.125732. https://pubmed.ncbi.nlm.nih.gov/23986476/
4. Clippinger, Amy K, Naismith, Teresa V, Yoo, Wonjin, Kast, David J, Hanson, Phyllis I. 2023. IST1 regulates select recycling pathways. In Traffic (Copenhagen, Denmark), 25, e12921. doi:10.1111/tra.12921. https://pubmed.ncbi.nlm.nih.gov/37926552/
5. Phillips, S A, Barr, V A, Haft, D H, Taylor, S I, Haft, C R. 2000. Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. In The Journal of biological chemistry, 276, 5074-84. doi:. https://pubmed.ncbi.nlm.nih.gov/11085978/
6. Clippinger, Amy K, Naismith, Teresa V, Yoo, Wonjin, Kast, David, Hanson, Phyllis I. 2023. IST1 regulates select endosomal recycling pathways. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.07.31.551359. https://pubmed.ncbi.nlm.nih.gov/37577466/
7. Barr, V A, Phillips, S A, Taylor, S I, Haft, C R. . Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. In Traffic (Copenhagen, Denmark), 1, 904-16. doi:. https://pubmed.ncbi.nlm.nih.gov/11208079/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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