C57BL/6JCya-Tcimem1flox/Cya
Common Name:
Tcim-flox
Product ID:
S-CKO-14400
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Tcim-flox
Strain ID
CKOCMP-69068-Tcim-B6J-VA
Gene Name
Product ID
S-CKO-14400
Gene Alias
1110065B09Rik; 1810011O10Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tcimem1flox/Cya mice (Catalog S-CKO-14400) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000052622
NCBI RefSeq
NM_026931
Target Region
Exon 1
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Tcim, whose full name is not explicitly given in the provided references, is one of the genes whose expression appears to mediate the association between the MIND diet and dementia [1]. The MIND diet is related to a specific brain transcriptomic profile, and Tcim might be involved in the underlying molecular mechanisms linking this diet to cognitive health.
No information regarding KO/CKO mouse models or other loss-of-function experiments on Tcim was found in the provided references.
In conclusion, Tcim potentially plays a role in the relationship between the MIND diet and cognitive health, specifically in relation to dementia. Although the exact mechanism remains unclear due to lack of information from gene-knockout models, its identification as a mediating gene in this context provides a starting point for further research into understanding the molecular basis of how diet impacts dementia risk.
References:
1. Li, Jun, Capuano, Ana W, Agarwal, Puja, Liang, Liming, Grodstein, Francine. 2024. The MIND diet, brain transcriptomic alterations, and dementia. In Alzheimer's & dementia : the journal of the Alzheimer's Association, 20, 5996-6007. doi:10.1002/alz.14062. https://pubmed.ncbi.nlm.nih.gov/39129336/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen