Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Mcemp1em1flox/Cya
Common Name:
Mcemp1-flox
Product ID:
S-CKO-14450
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Mcemp1-flox
Strain ID
CKOCMP-69189-Mcemp1-B6J-VA
Gene Name
Mcemp1
Product ID
S-CKO-14450
Gene Alias
1810033B17Rik
Background
C57BL/6JCya
NCBI ID
69189
Modification
Conditional knockout
Chromosome
8
Phenotype
MGI:1916439
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mcemp1em1flox/Cya mice (Catalog S-CKO-14450) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000014118
NCBI RefSeq
NM_026985
Target Region
Exon 3~7
Size of Effective Region
~3.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MCEMP1, also known as C19ORF59, is a mast cell-expressed membrane protein. In lung mast cells, it functions as an adaptor for KIT, promoting SCF-mediated mast cell proliferation through its cytoplasmic immunoreceptor tyrosine-based activation motif and enhancing KIT autophosphorylation and activation [1]. It may also be involved in immune-related signaling pathways, as indicated by its association with various diseases related to immune responses [2,7].

In mouse models, Mcemp1 -deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma models, demonstrating that MCEMP1 is crucial for SCF-induced peritoneal mast cell proliferation in vitro and lung mast cell expansion in vivo [1]. In other diseases, such as advanced gastric cancer, high MCEMP1 expression is related to poor survival and is correlated with immune infiltration, potentially affecting prognosis by regulating immune cell function [2]. In septic shock, MCEMP1 is one of six hub genes identified as potential diagnostic markers [3]. In lung adenocarcinoma, low MCEMP1 expression promotes tumor progression [4]. In coronary artery disease, MCEMP1 may play an important role as it is associated with immune cell infiltration, and knockdown of MCEMP1 in HUVECs affects cell proliferation, apoptosis, and inflammatory factor expression [5]. In idiopathic pulmonary fibrosis, MCEMP1 is highly expressed in classical monocytes and alveolar macrophages, regulated by TGFβ, and participates in cell chemotaxis, adhesion, and migration [6,8].

In conclusion, MCEMP1 is a significant gene involved in mast cell-related functions and immune-related signaling. Its role in various disease conditions, as revealed by studies including those using mouse models, highlights its potential as a biomarker and therapeutic target in diseases such as asthma, cancer, septic shock, coronary artery disease, and idiopathic pulmonary fibrosis.

References:
1. Choi, Youn Jung, Yoo, Ji-Seung, Jung, Kyle, Asosingh, Kewal, Jung, Jae U. 2023. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. In Nature communications, 14, 2045. doi:10.1038/s41467-023-37873-3. https://pubmed.ncbi.nlm.nih.gov/37041174/
2. Wang, Daijun, Gu, Yanmei, Huo, Chengdong, Teng, Muzhou, Li, Yumin. 2022. MCEMP1 is a potential therapeutic biomarker associated with immune infiltration in advanced gastric cancer microenvironment. In Gene, 840, 146760. doi:10.1016/j.gene.2022.146760. https://pubmed.ncbi.nlm.nih.gov/35905854/
3. Kong, Chang, Zhu, Yurun, Xie, Xiaofan, Wu, Jiayu, Qian, Meizi. 2023. Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study. In Frontiers in immunology, 14, 1184700. doi:10.3389/fimmu.2023.1184700. https://pubmed.ncbi.nlm.nih.gov/37359526/
4. Ling, Liqun, Hu, Tianqi, Zhou, Chenkang, Wang, Yumin, Wang, Junjun. . Low Expression MCEMP1 Promotes Lung Adenocarcinoma Progression and its Clinical Value. In Current cancer drug targets, 25, 281-293. doi:10.2174/0115680096292054240409070618. https://pubmed.ncbi.nlm.nih.gov/38676531/
5. Ye, Wei, Shen, Bo, Tang, Qizhu, Xie, Lili, He, Qi. 2024. Identification of a novel immune infiltration-related gene signature, MCEMP1, for coronary artery disease. In PeerJ, 12, e18135. doi:10.7717/peerj.18135. https://pubmed.ncbi.nlm.nih.gov/39346078/
6. Perrot, Carole Y, Karampitsakos, Theodoros, Unterman, Avraham, Bandyopadhyay, Debabrata, Herazo-Maya, Jose D. 2023. Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.10.07.561349. https://pubmed.ncbi.nlm.nih.gov/37873485/
7. Huang, Pu, Liu, Yawen, Jia, Baoqing. 2022. The Expression, Prognostic Value, and Immunological Correlation of MCEMP1 and its Potential Role in Gastric Cancer. In Journal of oncology, 2022, 8167496. doi:10.1155/2022/8167496. https://pubmed.ncbi.nlm.nih.gov/35378772/
8. Perrot, Carole Y, Karampitsakos, Theodoros, Unterman, Avraham, Bandyopadhyay, Debabrata, Herazo-Maya, Jose D. 2024. Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner. In American journal of physiology. Cell physiology, 326, C964-C977. doi:10.1152/ajpcell.00563.2023. https://pubmed.ncbi.nlm.nih.gov/38189137/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest