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C57BL/6JCya-Tbccd1em1flox/Cya
Common Name:
Tbccd1-flox
Product ID:
S-CKO-14865
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tbccd1-flox
Strain ID
CKOCMP-70573-Tbccd1-B6J-VA
Gene Name
Tbccd1
Product ID
S-CKO-14865
Gene Alias
5730478M09Rik
Background
C57BL/6JCya
NCBI ID
70573
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:1917823
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tbccd1em1flox/Cya mice (Catalog S-CKO-14865) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000004576
NCBI RefSeq
NM_001081368
Target Region
Exon 4
Size of Effective Region
~1.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tbccd1, a protein related to tubulin cofactor C, is crucial for internal cell organization. It localizes at the centrosome, spindle midzone, midbody, and basal bodies of cilia. It plays roles in centrosome positioning, Golgi apparatus organization, and is associated with cytoskeletal filament formation [1,3]. Genetic models are valuable for studying Tbccd1's functions in various organisms.

In RPE-1 cells, knockdown of Tbccd1 led to centrosome dissociation from the nucleus, Golgi apparatus disorganization, larger cell size, less efficient primary cilia assembly, and slower cell migration in wound-healing assays, while major microtubule-nucleating activity was unaffected [1]. In Ectocarpus, mutations in the DIS gene encoding TBCCd1 caused loss of basal structures, with abnormalities in the germinating initial cell such as increased cell size, Golgi disorganization, microtubule network disruption, and aberrant nucleus positioning [2]. In Trypanosoma brucei, loss of Tbccd1 led to disorganization of the Golgi 'bi-lobe' architecture and loss of centriole-kinetoplast linkage [3]. In Chlamydomonas reinhardtii, Tbccd1 is required for mother-daughter centriole linkage [3,4]. In asq2 mutant cells (where ASQ2 encodes Tbccd1), there were defects in centriole number control, centriole positioning, and spindle orientation due to perturbed centriole linkage [4].

In conclusion, Tbccd1 is essential for multiple cellular processes including centrosome and Golgi apparatus positioning, centriole linkage, and cytoskeletal organization. Model-based research, especially through loss-of-function experiments, has revealed its significance in different organisms. Although no specific disease areas related to Tbccd1 KO/CKO mouse models were mentioned in the provided references, the understanding of its functions can potentially contribute to insights in relevant disease-related cell biology [1-3,6].

References:
1. Gonçalves, João, Nolasco, Sofia, Nascimento, Rute, Zabala, Juan Carlos, Soares, Helena. 2010. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. In EMBO reports, 11, 194-200. doi:10.1038/embor.2010.5. https://pubmed.ncbi.nlm.nih.gov/20168327/
2. Godfroy, Olivier, Uji, Toshiki, Nagasato, Chikako, Cock, J Mark, Coelho, Susana M. 2017. DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination in Ectocarpus. In The Plant cell, 29, 3102-3122. doi:10.1105/tpc.17.00440. https://pubmed.ncbi.nlm.nih.gov/29208703/
3. André, Jane, Harrison, Stephanie, Towers, Katie, McKean, Paul G, Ginger, Michael L. 2013. The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation. In Journal of cell science, 126, 5350-6. doi:10.1242/jcs.136515. https://pubmed.ncbi.nlm.nih.gov/24101722/
4. Feldman, Jessica L, Marshall, Wallace F. . ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation. In Current biology : CB, 19, 1238-43. doi:10.1016/j.cub.2009.05.071. https://pubmed.ncbi.nlm.nih.gov/19631545/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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