C57BL/6JCya-Esm1em1flox/Cya
Common Name
Esm1-flox
Product ID
S-CKO-15131
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-71690-Esm1-B6J-VA
When using this mouse strain in a publication, please cite “Esm1-flox Mouse (Catalog S-CKO-15131) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Esm1-flox
Strain ID
CKOCMP-71690-Esm1-B6J-VA
Gene Name
Product ID
S-CKO-15131
Gene Alias
0610042H23Rik, ESM-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000038144
NCBI RefSeq
NM_023612
Target Region
Exon 1
Size of Effective Region
~2.8 kb
Overview of Gene Research
Esm1, also known as endocan, is a secreted protein. It has been implicated in promoting proliferation, angiogenesis, and other oncogenic processes in multiple cancers [1-10]. It is associated with various signaling pathways, such as the Akt pathway, which it activates to drive cancer-related biological functions [1, 4-7].
In ovarian cancer, Esm1 knockdown inhibited cell proliferation, apoptosis escape, the cell cycle, angiogenesis, migration, and invasion. Hypoxia-induced Esm1 upregulation promoted the Warburg effect and vasculogenic mimicry through the PKM2-dependent mechanism [1,2].
In gastric cancer, Esm1 promoted angiogenesis and peritoneal metastasis by binding to c-Met and activating the MAPK/ERK pathway, and also triggered epithelial-to-mesenchymal transition via the EGFR/HER3-Akt/ANGPT2 pathway [3,4].
In colorectal cancer, Esm1 promoted angiogenesis by activating the PI3K/Akt/mTOR pathway [5].
In triple-negative breast cancer, Esm1 promoted cell proliferation through the AKT/NF-κB/Cyclin D1 pathway [6].
In esophageal squamous cell carcinoma, silencing Esm1 suppressed cell proliferation, migration, and invasion [7].
In cervical squamous cell carcinoma, Esm1 overexpression promoted carcinoma angiogenesis and tumor progression through the VEGF/ERK signaling pathway [8].
In conclusion, Esm1 is a crucial factor in promoting cancer-related processes in multiple cancer types, including ovarian, gastric, colorectal, triple-negative breast, esophageal squamous cell, and cervical squamous cell carcinomas. The study of Esm1 using gene knockdown and other functional studies in these cancer models has revealed its significant role in cancer development, progression, and angiogenesis, suggesting it could be a potential therapeutic target and prognostic biomarker for these diseases.
References：
1. Li, Yu-Kun, Zeng, Tian, Guan, Yang, Zhang, Qun-Feng, Zou, Juan. 2023. Validation of ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic Significance. In International journal of biological sciences, 19, 258-280. doi:10.7150/ijbs.66839. https://pubmed.ncbi.nlm.nih.gov/36594088/
2. Zhang, Juan, Ouyang, Fan, Gao, Anbo, Long, Yunzhu, Li, Yukun. 2024. ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment. In Molecular cancer, 23, 94. doi:10.1186/s12943-024-02009-8. https://pubmed.ncbi.nlm.nih.gov/38720298/
3. Yang, Jiaoyang, Shu, Gege, Chen, Tao, Li, Dongbao, Zhou, Jin. 2023. ESM1 Interacts with c-Met to Promote Gastric Cancer Peritoneal Metastasis by Inducing Angiogenesis. In Cancers, 16, . doi:10.3390/cancers16010194. https://pubmed.ncbi.nlm.nih.gov/38201620/
4. Yang, Yi-Chieh, Ho, Ko-Hao, Pan, Ke-Fan, Lee, Wei-Jiunn, Chien, Ming-Hsien. 2024. ESM1 facilitates the EGFR/HER3-triggered epithelial-to-mesenchymal transition and progression of gastric cancer via modulating interplay between Akt and angiopoietin-2 signaling. In International journal of biological sciences, 20, 4819-4837. doi:10.7150/ijbs.100276. https://pubmed.ncbi.nlm.nih.gov/39309430/
5. Yang, Liqun, Dong, Zhigang, Li, Shuyu, Chen, Tieliang. 2023. ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression. In Aging, 15, 2920-2936. doi:10.18632/aging.204559. https://pubmed.ncbi.nlm.nih.gov/37100467/
6. Liu, Wentong, Yang, Yang, He, Bincan, Zhang, Min, Dong, Zhiqiang. . ESM1 promotes triple-negative breast cancer cell proliferation through activating AKT/NF-κB/Cyclin D1 pathway. In Annals of translational medicine, 9, 533. doi:10.21037/atm-20-7005. https://pubmed.ncbi.nlm.nih.gov/33987231/
7. Li, Juan, Yang, Dong, Zhang, Cong, Dai, Suli, Shan, Baoen. 2022. ESM1 Is a Promising Therapeutic Target and Prognostic Indicator for Esophageal Carcinogenesis/Esophageal Squamous Cell Carcinoma. In BioMed research international, 2022, 5328192. doi:10.1155/2022/5328192. https://pubmed.ncbi.nlm.nih.gov/35937390/
8. Li, Dan, Su, Xiaomin, Xue, Shen, Tang, Xianbing, Huang, Yugang. 2023. Targeting ESM1/ VEGFα signaling axis: a promising therapeutic avenue for angiogenesis in cervical squamous cell carcinoma. In Journal of Cancer, 14, 1725-1735. doi:10.7150/jca.84654. https://pubmed.ncbi.nlm.nih.gov/37476182/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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