C57BL/6JCya-Wdr89em1flox/Cya
Common Name:
Wdr89-flox
Product ID:
S-CKO-15441
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Wdr89-flox
Strain ID
CKOCMP-72338-Wdr89-B6J-VA
Gene Name
Product ID
S-CKO-15441
Gene Alias
2600001A11Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Wdr89em1flox/Cya mice (Catalog S-CKO-15441) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062370
NCBI RefSeq
NM_028203
Target Region
Exon 2
Size of Effective Region
~4.2 kb
Detailed Document
Overview of Gene Research
Wdr89, a member of the WD40-repeat (WDR) protein family, is involved in multiple biological processes. However, its exact function and associated pathways are still being explored. Genetic models, such as gene knockout mouse models, could potentially offer insights into its role in normal biological functions and disease states [4].
In a study on severe COVID-19, a gene-based analysis identified a novel significant association with Wdr89, suggesting its possible role in the disease [1]. In allergic rhinitis, serum protein Wdr89 was found to be closely related to the pathogenesis and played a role in the regulation of rush immunotherapy [2]. A study on burned intestinal mucosa showed that CircSugp1 promoted the repair of intestinal mucosal damage in burned mice by upregulating Wdr89 through an alternative polyadenylation-mediated mechanism [3]. In Cronkhite-Canada syndrome, genetic variants in Wdr89 were identified, indicating potential roles of innate immune responses and glycosylation in the pathogenesis [5]. In crossbred dairy cattle in Ethiopia, Wdr89 was identified as a candidate gene associated with milk-related traits [6]. In adamantinomatous craniopharyngioma, a Wdr89-based nomogram model was constructed to predict immune classification [7]. In glioblastoma, Wdr89 was identified as a potential drug target through whole exome sequencing analysis [8].
In summary, Wdr89 appears to be involved in a variety of biological processes and disease conditions, including immune-related diseases, mucosal repair, and potentially in the pathogenesis of certain syndromes and cancers. Although the exact mechanisms remain to be fully elucidated, studies suggest its importance in these areas, and further research using genetic models may help to clarify its functions and implications in disease.
References:
1. Garg, Elika, Arguello-Pascualli, Paola, Vishnyakova, Olga, Sun, Lei, Elliott, Lloyd T. 2024. Canadian COVID-19 host genetics cohort replicates known severity associations. In PLoS genetics, 20, e1011192. doi:10.1371/journal.pgen.1011192. https://pubmed.ncbi.nlm.nih.gov/38517939/
2. Jiang, Yinli, Zhu, Xinhua, Tang, Siyi, Lei, Pengtai, Liu, Yuehui. . [Study on expression and mechanism of serum differential proteins after rush immunotherapy of allergic rhinitis]. In Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 34, 683-689. doi:10.13201/j.issn.2096-7993.2020.08.003. https://pubmed.ncbi.nlm.nih.gov/32842198/
3. Liao, Yu, Li, Ran, Zhang, Hao, Meng, Fanze, Sun, Yong. 2024. CircSugp1 interacts with CPSF6 to modulate intestinal mucosa repair by regulating alternative polyadenylation-mediated shortening of the Wdr89 3'UTR. In International immunopharmacology, 145, 113793. doi:10.1016/j.intimp.2024.113793. https://pubmed.ncbi.nlm.nih.gov/39662264/
4. Kannan, Meghna, Bayam, Efil, Wagner, Christel, Godin, Juliette D, Yalcin, Binnaz. 2017. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. In Proceedings of the National Academy of Sciences of the United States of America, 114, E9308-E9317. doi:10.1073/pnas.1713625114. https://pubmed.ncbi.nlm.nih.gov/29078390/
5. Liu, Shuang, Zhang, Run Feng, You, Yan, Li, Ji, Qian, Jia Ming. 2022. The genomic landscape of Cronkhite-Canada syndrome: Possible clues for pathogenesis. In Journal of digestive diseases, 23, 288-294. doi:10.1111/1751-2980.13101. https://pubmed.ncbi.nlm.nih.gov/35678525/
6. Rekik, B, Mestawet, T, Girma, A, Besufekad, J, Meseret, S. 2024. Genome-Wide Association Study for Test-Day Milk Yield, Proteins, and Composition Traits of Crossbred Dairy Cattle in Ethiopia. In International journal of genomics, 2024, 1472779. doi:10.1155/2024/1472779. https://pubmed.ncbi.nlm.nih.gov/39473539/
7. Yuan, Feng, Cai, Xiangming, Zhu, Junhao, Cong, Zixiang, Ma, Chiyuan. 2021. A Novel Immune Classification for Predicting Immunotherapy Responsiveness in Patients With Adamantinomatous Craniopharyngioma. In Frontiers in neurology, 12, 704130. doi:10.3389/fneur.2021.704130. https://pubmed.ncbi.nlm.nih.gov/34966342/
8. Sarker, Arnob, Uddin, Burhan, Ahmmed, Reaz, Aziz, Md Abdul, Mollah, Md Nurul Haque. 2025. Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing. In Heliyon, 11, e42052. doi:10.1016/j.heliyon.2025.e42052. https://pubmed.ncbi.nlm.nih.gov/39906820/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen