Prr5l, also known as proline rich 5 like, is a protein-coding gene. It is a subunit of the mTORC2 complex and is involved in regulating cellular functions such as cell migration and apoptosis. The mTOR (mechanistic target of rapamycin) pathway, in which Prr5l participates, is crucial for cell growth, metabolism, and survival [1,2,3].

Lysophosphatidic acid (LPA) can lead to the degradation of PRR5L, which promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12, being important for fibroblast migration and pulmonary fibrosis development [1]. Also, PRR5L binds specifically to mTORC2 via Rictor and/or SIN1. Although not required for mTORC2 integrity or kinase activity, its knockdown reduces apoptosis, suggesting that mTORC2-dissociated PRR5L may promote apoptosis when mTOR is hyperactive [2].

In conclusion, Prr5l plays a significant role in regulating cell migration and apoptosis through its association with the mTORC2 complex. The findings from functional studies related to Prr5l contribute to understanding biological processes in areas such as pulmonary fibrosis development, providing insights into potential disease mechanisms and possible therapeutic targets.