C57BL/6JCya-Ms4a6cem1flox/Cya
Common Name:
Ms4a6c-flox
Product ID:
S-CKO-15727
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ms4a6c-flox
Strain ID
CKOCMP-73656-Ms4a6c-B6J-VA
Gene Name
Product ID
S-CKO-15727
Gene Alias
2200009H22Rik; 2210417N07Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ms4a6cem1flox/Cya mice (Catalog S-CKO-15727) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000165310
NCBI RefSeq
NM_028595
Target Region
Exon 5~6
Size of Effective Region
~3.0 kb
Detailed Document
Overview of Gene Research
Ms4a6c, whose full name remains to be comprehensively defined, seems to be associated with myeloid cell-related functions. From the references, myeloid cells play critical roles in the central nervous system (CNS) immune defense, maintaining tissue homeostasis and responding to injury or disease [1].
In experimental autoimmune encephalomyelitis (EAE) mice, Ms4a6c shows differential expression. During the high clinical score (HCS) of EAE, its mRNA expression is increased. Herceptin treatment can reduce the levels of Ms4a6c mRNA, except in certain regimens where Cd74 and Clec7a also show increased levels at HCS [2].
In the context of CNS, long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells (monocytes) is achieved. A monocyte signature is identified, and Ms4a6c is among the genes with up-regulation in this signature. This long-term engraftment of monocytes in the CNS also induces brain region-dependent alterations in transcription profiles, astrocytes, neuronal structures, and cognition [1].
In conclusion, Ms4a6c appears to be involved in myeloid cell-related processes in the CNS, especially in the context of diseases like EAE. Its differential expression in EAE mice and its presence in the monocyte signature during CNS myeloid cell colonization highlight its potential importance in understanding CNS-related immune responses and disease mechanisms.
References:
1. Hohsfield, Lindsay A, Najafi, Allison R, Ghorbanian, Yasamine, Inlay, Mathew A, Green, Kim N. 2020. Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS. In Journal of neuroinflammation, 17, 279. doi:10.1186/s12974-020-01931-0. https://pubmed.ncbi.nlm.nih.gov/32951604/
2. Al-Ani, Mena, Elemam, Noha Mousaad, Hachim, Ibrahim Y, Bendardaf, Riyad, Maghazachi, Azzam A. 2021. Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment. In Journal of inflammation research, 14, 2601-2617. doi:10.2147/JIR.S310535. https://pubmed.ncbi.nlm.nih.gov/34168483/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen