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C57BL/6JCya-Psma8em1flox/Cya
Common Name:
Psma8-flox
Product ID:
S-CKO-15736
Background:
C57BL/6JCya
Product Type
Age
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Sex
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Basic Information
Strain Name
Psma8-flox
Strain ID
CKOCMP-73677-Psma8-B6J-VA
Gene Name
Psma8
Product ID
S-CKO-15736
Gene Alias
2410072D24Rik
Background
C57BL/6JCya
NCBI ID
73677
Modification
Conditional knockout
Chromosome
18
Phenotype
MGI:1920927
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Psma8em1flox/Cya mice (Catalog S-CKO-15736) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000040860
NCBI RefSeq
NM_001163609
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Psma8, also known as α4s, is a testis-specific proteasomal subunit. It is crucial for proper meiotic exit during spermatogenesis, with its associated proteasomes being essential for the degradation of meiotic proteins and the progression of meiosis I. This process is tightly regulated by ubiquitination and proteasomal degradation, and Psma8-containing proteasomes are involved in histone degradation during DNA repair in spermatocytes [1,2,3].

In Psma8-deficient mice, meiotic homologous recombination is proficient, but there are alterations in the proteostasis of key meiotic players like SYCP3, SYCP1, CDK1, and TRIP13. This leads to an accumulation of spermatocytes in metaphase I and II, resulting in either massive apoptosis or the generation of a low number of aberrant round spermatids that apoptose before histone replacement. Additionally, deletion of Psma8 decreases the abundance of proteasome in testes, and meiotic proteins that should be degraded at late prophase I remain stable, causing male infertility as spermatocytes are arrested at the M-phase. However, Psma8 is neither expressed nor required for female meiotic progression [1,2].

In conclusion, Psma8 is essential for the proper progression of meiosis during spermatogenesis, specifically for the degradation of meiotic proteins and histone degradation at DNA damage loci. The study of Psma8-deficient mouse models has provided valuable insights into male infertility, highlighting its potential as a target for male contraception or treatment of male infertility.

References:
1. Gómez-H, Laura, Felipe-Medina, Natalia, Condezo, Yazmine B, Llano, Elena, Pendas, Alberto M. 2019. The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility. In PLoS genetics, 15, e1008316. doi:10.1371/journal.pgen.1008316. https://pubmed.ncbi.nlm.nih.gov/31437213/
2. Zhang, Qianting, Ji, Shu-Yan, Busayavalasa, Kiran, Shao, Jingchen, Yu, Chao. 2019. Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome. In Nature communications, 10, 3387. doi:10.1038/s41467-019-11346-y. https://pubmed.ncbi.nlm.nih.gov/31358751/
3. Zhang, Zi-Hui, Jiang, Tian-Xia, Chen, Lian-Bin, Gao, Fei, Qiu, Xiao-Bo. 2020. Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes. In The Journal of biological chemistry, 296, 100130. doi:10.1074/jbc.RA120.016485. https://pubmed.ncbi.nlm.nih.gov/33262216/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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