C57BL/6JCya-Ttc27em1flox/Cya
Common Name:
Ttc27-flox
Product ID:
S-CKO-15909
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Ttc27-flox
Strain ID
CKOCMP-74196-Ttc27-B6J-VA
Gene Name
Product ID
S-CKO-15909
Gene Alias
2610511O17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ttc27em1flox/Cya mice (Catalog S-CKO-15909) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024882
NCBI RefSeq
NM_152817
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Ttc27, with homologs like TRD-1 in C. elegans, is involved in important biological processes. In C. elegans, TRD-1 regulates cell fate choice in the germline and epidermis [2]. In mammals, it may be associated with stem cell pluripotency as its ortholog was identified in a comparative transcriptomic analysis of stem cells from planarians, mice, and humans [3].
In a study on hypoxia in mouse brain, Ttc27 was downregulated in both the cortical and hippocampal regions following chronic constant hypoxia (CCH) and chronic intermittent hypoxia (CIH) [4]. Also, an association was observed between TTC27 and white matter hyperintensities (WMH) in a GWAS for AD-related quantitative measures [1].
In summary, Ttc27 plays a role in cell fate determination, may be linked to stem cell pluripotency, and is associated with hypoxia-related gene expression changes in the brain and WMH in the context of Alzheimer's disease-related traits. Research on Ttc27, especially through in vivo models like mouse studies, helps in understanding its functions and implications in these biological processes and disease conditions.
References：
1. Melville, Scott A, Buros, Jacqueline, Parrado, Antonio R, Saykin, Andrew J, Farrer, Lindsay A. 2012. Multiple loci influencing hippocampal degeneration identified by genome scan. In Annals of neurology, 72, 65-75. doi:10.1002/ana.23644. https://pubmed.ncbi.nlm.nih.gov/22745009/
2. Hughes, Samantha, Wilkinson, Henry, Gilbert, Sophie P R, Ding, Siyu Serena, Woollard, Alison. 2014. The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis. In PloS one, 9, e114998. doi:10.1371/journal.pone.0114998. https://pubmed.ncbi.nlm.nih.gov/25493563/
3. Labbé, Roselyne M, Irimia, Manuel, Currie, Ko W, Blencowe, Benjamin J, Pearson, Bret J. . A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals. In Stem cells (Dayton, Ohio), 30, 1734-45. doi:10.1002/stem.1144. https://pubmed.ncbi.nlm.nih.gov/22696458/
4. Zhou, Dan, Wang, Jiyi, Zapala, Matthew A, Schork, Nicholas J, Haddad, Gabriel G. 2007. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. In Physiological genomics, 32, 370-9. doi:. https://pubmed.ncbi.nlm.nih.gov/18056785/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen