C57BL/6JCya-Mamstrem1flox/Cya
Common Name:
Mamstr-flox
Product ID:
S-CKO-16032
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mamstr-flox
Strain ID
CKOCMP-74490-Mamstr-B6J-VA
Gene Name
Product ID
S-CKO-16032
Gene Alias
2810022D01Rik; 5430432N15Rik; Mastr
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mamstrem1flox/Cya mice (Catalog S-CKO-16032) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000148532
NCBI RefSeq
NM_172418
Target Region
Exon 3~7
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Mamstr, also known as MASTR, is a protein belonging to the myocardin family. It binds to the transcription factor serum response factor (SRF) and acts as a co-activator. It is involved in regulating genes relevant to myogenic differentiation, motile function, and also plays roles in lipid and glucose metabolism [3]. It has been associated with multiple biological processes including transcriptional regulation, metabolic pathways, and cell development and differentiation [1].
In the dy2J/dy2J mouse model of Lama2-CMD, downregulation of Mamstr was detected compared to wild-type mice. Along with Pax7 and Pax3, the downregulation of Mamstr may explain the progressive dystrophic process in this model, as opposed to the massive regeneration seen in the mdx mouse model [2].
In summary, Mamstr is important for myogenic-related processes and metabolism. Its downregulation in the dy2J/dy2J mouse model of Lama2-CMD reveals its potential role in muscle regeneration and disease progression, highlighting its significance in understanding the pathophysiology of Lama2-CMD and potentially guiding the development of new therapies [2].
References：
1. Li, Chenlei, Zhang, Zhe, Wei, Yilin, Yang, Feng, Han, Xuelei. 2023. Genome-Wide Analysis of MAMSTR Transcription Factor-Binding Sites via ChIP-Seq in Porcine Skeletal Muscle Fibroblasts. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13111731. https://pubmed.ncbi.nlm.nih.gov/37889674/
2. Yanay, Nurit, Elbaz, Moran, Konikov-Rozenman, Jenya, Mitrani-Rosenbaum, Stella, Nevo, Yoram. . Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD. In Human molecular genetics, 28, 3369-3390. doi:10.1093/hmg/ddz180. https://pubmed.ncbi.nlm.nih.gov/31348492/
3. Swärd, Karl, Stenkula, Karin G, Rippe, Catarina, Gomez, Maria F, Albinsson, Sebastian. 2016. Emerging roles of the myocardin family of proteins in lipid and glucose metabolism. In The Journal of physiology, 594, 4741-52. doi:10.1113/JP271913. https://pubmed.ncbi.nlm.nih.gov/27060572/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen