C57BL/6JCya-Elovl7em1flox/Cya
Common Name:
Elovl7-flox
Product ID:
S-CKO-16051
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Elovl7-flox
Strain ID
CKOCMP-74559-Elovl7-B6J-VA
Gene Name
Product ID
S-CKO-16051
Gene Alias
9130013K24Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Elovl7em1flox/Cya mice (Catalog S-CKO-16051) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022207
NCBI RefSeq
NM_029001
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Elovl7, or Elongation of Very Long Fatty Acids Protein 7, is a key enzyme in the synthesis of very long-chain fatty acids (VLCFAs). It participates in fatty acid synthesis and metabolism pathways, which are crucial for numerous biological processes including cell membrane formation, energy storage, and cell-signaling [1,2]. Genetic models, such as gene knockout models, can be valuable for studying its function.
A study on Mdr2-knockout models found that Elovl7 was significantly associated with liver fibrosis S ≥ 2, suggesting its potential involvement in the activation of hepatic stellate cells and the TGFβ signaling pathway [1]. In prostate cancer cells, knockdown of Elovl7 led to a drastic attenuation of cell growth, indicating its role in prostate cancer growth through saturated long-chain fatty acid metabolism [2]. In human cytomegalovirus (HCMV) infection, Elovl7 knockdown impaired HCMV-induced fatty acid elongation, particle release, and infectivity, showing its importance for HCMV replication [3].
In conclusion, Elovl7 is essential for fatty acid synthesis and metabolism. Model-based research, especially through gene knockdown or knockout experiments, has revealed its significance in diseases like liver fibrosis, prostate cancer, and in the context of viral infections such as HCMV. These findings contribute to our understanding of disease mechanisms and may offer potential therapeutic targets.
References:
1. Wang, W-M, Yang, Z-G, Liu, C, Dong, Q. . ELOVL fatty acid elongase 7 (ELOVL7), upregulated by Mdr2-knockout, predicts advanced liver fibrosis in patients with chronic hepatitis B. In European review for medical and pharmacological sciences, 27, 1954-1970. doi:10.26355/eurrev_202303_31560. https://pubmed.ncbi.nlm.nih.gov/36930494/
2. Tamura, Kenji, Makino, Asami, Hullin-Matsuda, Françoise, Nakamura, Yusuke, Nakagawa, Hidewaki. 2009. Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. In Cancer research, 69, 8133-40. doi:10.1158/0008-5472.CAN-09-0775. https://pubmed.ncbi.nlm.nih.gov/19826053/
3. Purdy, John G, Shenk, Thomas, Rabinowitz, Joshua D. 2015. Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. In Cell reports, 10, 1375-85. doi:10.1016/j.celrep.2015.02.003. https://pubmed.ncbi.nlm.nih.gov/25732827/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen