C57BL/6JCya-Lysmd4em1flox/Cya
Common Name:
Lysmd4-flox
Product ID:
S-CKO-16159
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lysmd4-flox
Strain ID
CKOCMP-75099-Lysmd4-B6J-VA
Gene Name
Product ID
S-CKO-16159
Gene Alias
4930506D23Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lysmd4em1flox/Cya mice (Catalog S-CKO-16159) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058771
NCBI RefSeq
NM_175215
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Check the content of the review Lysmd4, details about its common aliases are not provided in the given references. Its essential functions, associated pathways are currently not clearly defined, but genetic models like those used in transcriptome-wide association studies can potentially shed light on its role.
In a multi-ethnic whole genome sequencing study, LYSMD4 was identified among loci demonstrating sex-specific associations with bone mineral density, specifically in men [2]. In another study, LYSMD4 was found to be one of the five novel genes associated with Alzheimer's disease in cortical brain tissue through transcriptome-wide association studies [1,3]. Also, in a case of Weill-Marchesani syndrome 4, a maternal submicroscopic deletion on chromosome 15q26.3 affected the sequences of LYSMD4 along with ADAMTS17 and CERS3 [4].
In conclusion, LYSMD4 shows associations with bone mineral density in men and Alzheimer's disease in cortical brain tissue. The case report also indicates its potential involvement in Weill-Marchesani syndrome 4. These findings from different research models help in understanding the role of LYSMD4 in various biological processes and disease conditions.
References：
1. Mews, Makaela A, Naj, Adam C, Griswold, Anthony J, Below, Jennifer E, Bush, William S. 2024. Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer's Disease. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.04.17.24305737. https://pubmed.ncbi.nlm.nih.gov/38699333/
2. Greenbaum, Jonathan, Su, Kuan-Jui, Zhang, Xiao, Shen, Hui, Deng, Hong-Wen. . A multiethnic whole genome sequencing study to identify novel loci for bone mineral density. In Human molecular genetics, 31, 1067-1081. doi:10.1093/hmg/ddab305. https://pubmed.ncbi.nlm.nih.gov/34673960/
3. Mews, Makaela A, Naj, Adam C, Griswold, Anthony J, Below, Jennifer E, Bush, William S. 2025. Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease. In Journal of Alzheimer's disease : JAD, 105, 228-244. doi:10.1177/13872877251326288. https://pubmed.ncbi.nlm.nih.gov/40111921/
4. Yu, Xiaowei, Kline, Brad, Han, Ying, Fan, Zhigang, Shi, Yan. 2022. Weill-Marchesani syndrome 4 caused by compound heterozygosity of a maternal submicroscopic deletion and a paternal nonsense variant in the ADAMTS17 gene: A case report. In American journal of ophthalmology case reports, 26, 101541. doi:10.1016/j.ajoc.2022.101541. https://pubmed.ncbi.nlm.nih.gov/35496767/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen