C57BL/6JCya-Slamf7em1flox/Cya
Common Name:
Slamf7-flox
Product ID:
S-CKO-16205
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slamf7-flox
Strain ID
CKOCMP-75345-Slamf7-B6J-VA
Gene Name
Product ID
S-CKO-16205
Gene Alias
19A; 19A24; 4930560D03Rik; CRACC; CS1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slamf7em1flox/Cya mice (Catalog S-CKO-16205) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000192195
NCBI RefSeq
NM_144539
Target Region
Exon 3~5
Size of Effective Region
~3.7 kb
Detailed Document
Overview of Gene Research
SLAMF7, also known as CRACC, CS1, CD319, is an Ig-like receptor expressed on various immune cells including macrophages, B cells, T cells, NK cells, etc. It plays a crucial role in regulating immune responses, especially in macrophage activation, phagocytosis, and B-cell and NK-cell functions. It is associated with pathways such as TLR-dependent MAPK and NF-κB signaling, and its regulation impacts cytokine production and cell-cell interactions [1,4,5,6].
In multiple myeloma, SLAMF7 is overexpressed and serves as an attractive immunotherapeutic target [2,7]. In hepatocellular carcinoma, loss of Slamf7 in liver-specific knockout mice led to increased carcinogenesis, metastasis, and immunosuppressive macrophage infiltration, highlighting its role in macrophage regulation and as a potential biomarker for immunotherapy response [3]. In CNS autoimmunity, SLAMF7-/-mice were more susceptible to experimental autoimmune encephalomyelitis (EAE), indicating its role in modulating B cells and adaptive immunity [5].
In conclusion, SLAMF7 is a key regulator in immune-related biological processes. Studies using gene knockout mouse models have revealed its importance in multiple diseases, including multiple myeloma, hepatocellular carcinoma, and CNS autoimmunity. These findings provide insights into disease mechanisms and potential therapeutic strategies targeting SLAMF7.
References:
1. Wu, Yongjian, Wang, Qiaohua, Li, Miao, Liu, Lei, Huang, Xi. 2023. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis. In The Journal of clinical investigation, 133, . doi:10.1172/JCI150224. https://pubmed.ncbi.nlm.nih.gov/36749634/
2. Chu, Emily, Wu, Jian, Kang, Stacey S, Kang, Yubin. 2023. SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma Treatments. In Current oncology (Toronto, Ont.), 30, 7891-7903. doi:10.3390/curroncol30090573. https://pubmed.ncbi.nlm.nih.gov/37754488/
3. Weng, Jialei, Wang, Zheng, Hu, Zhiqiu, Zhou, Chenhao, Ren, Ning. . Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy. In Cancer research, 84, 1817-1833. doi:10.1158/0008-5472.CAN-23-3106. https://pubmed.ncbi.nlm.nih.gov/38484085/
4. Chen, Jun, Zhong, Ming-Chao, Guo, Huaijian, Danska, Jayne S, Veillette, André. 2017. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. In Nature, 544, 493-497. doi:10.1038/nature22076. https://pubmed.ncbi.nlm.nih.gov/28424516/
5. O'Connell, Patrick, Blake, Maja K, Godbehere, Sarah, Amalfitano, Andrea, Aldhamen, Yasser A. 2022. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity. In Journal of neuroinflammation, 19, 241. doi:10.1186/s12974-022-02594-9. https://pubmed.ncbi.nlm.nih.gov/36199066/
6. Gutierrez-Guerrero, Arturo, Mancilla-Herrera, Ismael, Maravillas-Montero, Jose L, Veillette, Andre, Cruz-Munoz, Mario E. 2021. SLAMF7 selectively favors degranulation to promote cytotoxicity in human NK cells. In European journal of immunology, 52, 62-74. doi:10.1002/eji.202149406. https://pubmed.ncbi.nlm.nih.gov/34693521/
7. Malaer, Joseph D, Mathew, Porunelloor A. 2017. CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma. In American journal of cancer research, 7, 1637-1641. doi:. https://pubmed.ncbi.nlm.nih.gov/28861320/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen