C57BL/6JCya-Smim15em1flox/Cya
Common Name:
Smim15-flox
Product ID:
S-CKO-16283
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Smim15-flox
Strain ID
CKOCMP-75616-Smim15-B6J-VA
Gene Name
Product ID
S-CKO-16283
Gene Alias
2810008M24Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Smim15em1flox/Cya mice (Catalog S-CKO-16283) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000095458
NCBI RefSeq
NM_001048250
Target Region
Exon 3
Size of Effective Region
~3.5 kb
Detailed Document
Overview of Gene Research
Smim15, short for Small Integral Membrane Protein 15, likely plays a role in the biological processes of South American Camelids. However, its exact function, associated pathways, and overall biological importance remain to be fully elucidated, and genetic models could potentially help in further functional studies.
In a study on South American Camelids, nine overlapping Runs Of Homozygosity (ROHs) were found in llama, with twenty-five loci annotated, including Smim15. These ROHs might be related to production traits or natural adaptation to harsh environments [1].
In conclusion, while the essential biological functions of Smim15 are not yet clearly defined, the discovery of its presence within ROHs in llamas suggests it could be associated with traits related to adaptation or production in South American Camelids. Further research, potentially using gene knockout or conditional knockout mouse models, could help reveal its role in specific biological processes or disease conditions.
References：
1. Pallotti, Stefano, Picciolini, Matteo, Antonini, Marco, Renieri, Carlo, Napolioni, Valerio. 2023. Genome-wide scan for runs of homozygosity in South American Camelids. In BMC genomics, 24, 470. doi:10.1186/s12864-023-09547-3. https://pubmed.ncbi.nlm.nih.gov/37605116/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen