C57BL/6JCya-Actrt3em1flox/Cya
Common Name:
Actrt3-flox
Product ID:
S-CKO-16527
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Actrt3-flox
Strain ID
CKOCMP-76652-Actrt3-B6J-VA
Gene Name
Product ID
S-CKO-16527
Gene Alias
1700119I24Rik; ARP-T3; Arpm1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Actrt3em1flox/Cya mice (Catalog S-CKO-16527) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047630
NCBI RefSeq
NM_029690
Target Region
Exon 2
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Actrt3 is a gene associated with telomere maintenance, a crucial cellular process [1,3]. It is also involved in the B cell activation mechanism, where it was identified as a crucial gene in the Be1 network [2]. Understanding Actrt3 can provide insights into the genetic mechanisms underlying multiple biological processes.
In multi-tissue transcriptome-wide association studies (TWAS), Actrt3 in the 3q26 region was found to be associated with genes involved in telomere maintenance and the development of multiple primary cancers [1,3]. In a study exploring B cell activation mechanisms, Actrt3 was among the central genes predicted by the topology analysis of protein-protein interaction (PPI) networks in Be1 cells, indicating its role in promoting immune system activation [2].
In conclusion, Actrt3 plays important roles in telomere maintenance, B cell activation, and immune system activation. Its association with the development of multiple primary cancers highlights its significance in cancer-related research. These findings from studies on Actrt3 contribute to our understanding of the underlying genetic mechanisms in these biological processes and disease conditions.
References：
1. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2024. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.10.29.24316326. https://pubmed.ncbi.nlm.nih.gov/39574869/
2. Fatehi, Razieh. . Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches. In Human antibodies, 28, 83-87. doi:10.3233/HAB-190393. https://pubmed.ncbi.nlm.nih.gov/31524152/
3. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2025. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In HGG advances, 6, 100413. doi:10.1016/j.xhgg.2025.100413. https://pubmed.ncbi.nlm.nih.gov/39910817/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen