C57BL/6JCya-Nudt17em1flox/Cya
Common Name:
Nudt17-flox
Product ID:
S-CKO-16802
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Nudt17-flox
Strain ID
CKOCMP-78373-Nudt17-B6J-VA
Gene Name
Product ID
S-CKO-16802
Gene Alias
2410015C20Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Nudt17em1flox/Cya mice (Catalog S-CKO-16802) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029742
NCBI RefSeq
NM_001162925
Target Region
Exon 1~6
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Nudt17, a member of the Nudix hydrolase family, has been shown to possess mRNA decapping activity in vitro, contributing to gene expression regulation and mRNA decay [2]. This activity may be involved in various biological processes, though the exact in-vivo pathways are still being explored. Genetic models, such as studying its polymorphisms, can provide insights into its roles in health and disease.
In a study on Chinese Han population, certain single-nucleotide polymorphisms (SNPs) of Nudt17, like rs9286836 and rs2004659, were associated with a decreased breast cancer risk. The G allele of rs9286836 and the carriers of rs2004659 G allele had reduced risks. Also, Nudt17 SNPs were associated with breast cancer risk under age, tumor size, and clinical stage stratification [1]. In male gout, the rs9286836 (Nudt17) variant showed significant associations in both discovery and replication cohorts [3]. In clear cell renal cell carcinoma, Nudt17 expression was predictive of prognosis, with low Nudt17 expression associated with poorer overall survival rates [4].
In conclusion, Nudt17's mRNA decapping function has implications for gene regulation. Studies on its polymorphisms and expression levels in models related to breast cancer, male gout, and clear cell renal cell carcinoma suggest its potential role in these disease areas, highlighting its importance in understanding disease mechanisms and potentially developing targeted therapies.
References:
1. Han, Junhui, Liang, Jing, Zhou, Wenqian, Zhang, Man, Jin, Tianbo. 2024. Association between NUDT17 polymorphisms and breast cancer risk. In Expert review of molecular diagnostics, 24, 459-466. doi:10.1080/14737159.2024.2353700. https://pubmed.ncbi.nlm.nih.gov/38756100/
2. Song, Man-Gen, Bail, Sophie, Kiledjian, Megerditch. 2013. Multiple Nudix family proteins possess mRNA decapping activity. In RNA (New York, N.Y.), 19, 390-9. doi:10.1261/rna.037309.112. https://pubmed.ncbi.nlm.nih.gov/23353937/
3. Chang, Ya-Sian, Lin, Chien-Yu, Liu, Ting-Yuan, Chang, Jan-Gowth, Chang, Shun-Jen. 2022. Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study. In Arthritis research & therapy, 24, 229. doi:10.1186/s13075-022-02917-4. https://pubmed.ncbi.nlm.nih.gov/36221101/
4. Wang, Yue, Wan, Fangning, Chang, Kun, Dai, Bo, Ye, Dingwei. 2017. NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. In Oncology letters, 14, 6121-6128. doi:10.3892/ol.2017.6997. https://pubmed.ncbi.nlm.nih.gov/29113256/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen