C57BL/6JCya-B230219D22Rikem1flox/Cya
Common Name:
B230219D22Rik-flox
Product ID:
S-CKO-16823
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
B230219D22Rik-flox
Strain ID
CKOCMP-78521-B230219D22Rik-B6J-VA
Gene Name
Product ID
S-CKO-16823
Gene Alias
D530037I19Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-B230219D22Rikem1flox/Cya mice (Catalog S-CKO-16823) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057844
NCBI RefSeq
NM_181278
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Check the content of the review
B230219D22Rik, which corresponds to C5orf24 in humans, encodes feimin. It is a key modulator of glucose homeostasis, as feimin is secreted from skeletal muscle during feeding, binds to MERTK, promoting glucose uptake and inhibiting glucose production via AKT activation. It is also expressed in microglial cells, potentially influencing stroke-related biological processes [1,2].
In glucose homeostasis, administration of feimin and insulin synergistically improves blood glucose levels in normal and diabetic mice. A specific SNP in MERTK reduces its association with feimin, leading to elevated post-prandial glucose and insulin levels in humans.
In stroke research, B230219D22Rik/C5orf24 expression was reduced in mouse and human cell stroke models. MR analysis showed increased C5orf24 levels were associated with a reduced stroke risk, and in vitro overexpression of C5orf24 in an OGD/R model of human microglial cells inhibited the expression of inflammatory factors IL-1β and IL-6 [1,2].
In conclusion, B230219D22Rik plays a crucial role in glucose homeostasis and stroke-related processes. Its study in mouse models has provided insights into diabetes and stroke, suggesting it could be a potential therapeutic target for these diseases.
References：
1. Shi, Xiaoliu, Hu, Xiao, Fang, Xinlei, Wang, Jiqiu, Wang, Yiguo. 2025. A feeding-induced myokine modulates glucose homeostasis. In Nature metabolism, 7, 68-83. doi:10.1038/s42255-024-01175-9. https://pubmed.ncbi.nlm.nih.gov/39747483/
2. Gao, Ran, Xu, Yaqi, Zhang, Min, Su, Wenting, Wang, Renxi. 2025. From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered. In Molecular neurobiology, , . doi:10.1007/s12035-025-04802-y. https://pubmed.ncbi.nlm.nih.gov/40038197/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen