C57BL/6JCya-Tac4em1flox/Cya
Common Name
Tac4-flox
Product ID
S-CKO-17121
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-93670-Tac4-B6J-VA
When using this mouse strain in a publication, please cite “Tac4-flox Mouse (Catalog S-CKO-17121) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tac4-flox
Strain ID
CKOCMP-93670-Tac4-B6J-VA
Gene Name
Product ID
S-CKO-17121
Gene Alias
PPT-C
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000021242
NCBI RefSeq
NM_053093
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Overview of Gene Research
Tac4, encoding hemokinin-1 (HK-1) in mouse and rat, is a gene related to the tachykinin family. It has diverse functions, being involved in pain-inflammation modulation, immune regulation, respiratory and endocrine functions, as well as tumor genesis. HK-1 binds to the NK1 receptor, similar to Substance P, and plays roles in various biological processes [3,5].
In Tac4-/-mice, stress-induced mechanical hyperalgesia was decreased, suggesting HK-1's role in stress-induced pain [1]. Also, TAC4-/-mice had an increase of "fraction B" pro-B cells in the bone marrow, indicating an inhibitory role of HK-1 on developing B cells [4]. Additionally, Tac4-/-mice showed anxiolytic and anti-depressant-like actions through an unknown target-mediated mechanism [6]. In terms of bone, Tac4-/-mice had reduced mechanical bone strength, revealing its role in bone quality [2].
In conclusion, Tac4, through its product HK-1, plays important roles in pain regulation, hematopoiesis, mental behaviors, and bone quality. Studies using Tac4-/-mouse models have provided insights into its functions in these areas, which may have implications for understanding and treating related diseases such as stress-induced pain, immune-related disorders, mental illnesses, and bone diseases.
References：
1. Borbély, Éva, Kecskés, Angéla, Kun, József, Palkovits, Miklós, Helyes, Zsuzsanna. 2023. Hemokinin-1 is a mediator of chronic restraint stress-induced pain. In Scientific reports, 13, 20030. doi:10.1038/s41598-023-46402-7. https://pubmed.ncbi.nlm.nih.gov/37973885/
2. Nethander, Maria, Movérare-Skrtic, Sofia, Kämpe, Anders, Richards, J Brent, Ohlsson, Claes. 2023. An atlas of genetic determinants of forearm fracture. In Nature genetics, 55, 1820-1830. doi:10.1038/s41588-023-01527-3. https://pubmed.ncbi.nlm.nih.gov/37919453/
3. Page, N M. . Hemokinins and endokinins. In Cellular and molecular life sciences : CMLS, 61, 1652-63. doi:. https://pubmed.ncbi.nlm.nih.gov/15224188/
4. Berger, Alexandra, Benveniste, Patricia, Corfe, Steven A, Iscove, Norman N, Paige, Christopher J. 2010. Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development. In Blood, 116, 3792-801. doi:10.1182/blood-2010-06-291062. https://pubmed.ncbi.nlm.nih.gov/20660792/
5. Borbély, Éva, Helyes, Zsuzsanna. 2016. Role of hemokinin-1 in health and disease. In Neuropeptides, 64, 9-17. doi:10.1016/j.npep.2016.12.003. https://pubmed.ncbi.nlm.nih.gov/27993375/
6. Borbély, Éva, Hajna, Zsófia, Nabi, Liza, Berger, Alexandra, Helyes, Zsuzsanna. 2016. Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice. In Brain, behavior, and immunity, 59, 219-232. doi:10.1016/j.bbi.2016.09.004. https://pubmed.ncbi.nlm.nih.gov/27621226/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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