Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Sirt1em1flox/Cya
Common Name:
Sirt1-flox
Product ID:
S-CKO-17175
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Sirt1-flox
Strain ID
CKOCMP-93759-Sirt1-B6J-VA
Gene Name
Sirt1
Product ID
S-CKO-17175
Gene Alias
SIR2L1; Sir2; Sir2a; Sir2alpha
Background
C57BL/6JCya
NCBI ID
93759
Modification
Conditional knockout
Chromosome
10
Phenotype
MGI:2135607
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sirt1em1flox/Cya mice (Catalog S-CKO-17175) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020257
NCBI RefSeq
NM_019812
Target Region
Exon 2~3
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Sirt1, short for silent information regulator sirtuin 1, is a highly conserved NAD+-dependent deacetylase belonging to the sirtuin family. It acts as a post-translational regulator, modulating multiple biological processes such as inflammation, aging, mitochondrial biogenesis, autophagy, and more. Sirt1 affects these processes by deacetylating various proteins including histones and non-histones, and is involved in signaling pathways like NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs [1,2].

Sirt1 knockout (KO) or conditional knockout (CKO) mouse models have been used to study its role in different diseases. For example, in the context of aging, decreased Sirt1 expression in mice is associated with the aging process, while increased expression can extend lifespan [2]. In myocardial ischemia-reperfusion, Sirt1 activation protects the heart, and it regulates autophagy during this process through deacetylation of FOXOs, ATGs, and LC3 [4]. In autoimmune diseases, Sirt1 may be a novel therapeutic target as its altered functions are likely involved in the disease progression [3]. In colorectal cancer, Sirt1 is a potential therapeutic target as it regulates processes like apoptosis, autophagy, and proliferation in CRC cells [5].

In conclusion, Sirt1 is a key regulator in multiple biological processes. Model-based research, especially using KO/CKO mouse models, has revealed its crucial roles in diseases related to aging, inflammation, autoimmunity, and cancer. Understanding Sirt1's functions provides potential therapeutic strategies for these disease areas.

References:
1. Yang, Yunshu, Liu, Yang, Wang, Yunwei, Tie, Jun, Hu, Dahai. 2022. Regulation of SIRT1 and Its Roles in Inflammation. In Frontiers in immunology, 13, 831168. doi:10.3389/fimmu.2022.831168. https://pubmed.ncbi.nlm.nih.gov/35359990/
2. Chen, Cui, Zhou, Min, Ge, Yuchen, Wang, Xiaobo. 2020. SIRT1 and aging related signaling pathways. In Mechanisms of ageing and development, 187, 111215. doi:10.1016/j.mad.2020.111215. https://pubmed.ncbi.nlm.nih.gov/32084459/
3. Shen, Pan, Deng, Xuan, Chen, Zhe, Yan, Jiahui, Tu, Shenghao. 2021. SIRT1: A Potential Therapeutic Target in Autoimmune Diseases. In Frontiers in immunology, 12, 779177. doi:10.3389/fimmu.2021.779177. https://pubmed.ncbi.nlm.nih.gov/34887866/
4. Ding, Xiaoqing, Zhu, Chenyu, Wang, Wenhong, Ma, Chunwei, Gao, Binghong. 2023. SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion. In Pharmacological research, 199, 106957. doi:10.1016/j.phrs.2023.106957. https://pubmed.ncbi.nlm.nih.gov/37820856/
5. Dong, Weiwei, Lu, Jinjing, Li, You, Xi, Zhuo, Cao, Shuo. 2024. SIRT1: a novel regulator in colorectal cancer. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 178, 117176. doi:10.1016/j.biopha.2024.117176. https://pubmed.ncbi.nlm.nih.gov/39059350/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest