C57BL/6JCya-A430005L14Rikem1flox/Cya
Common Name:
A430005L14Rik-flox
Product ID:
S-CKO-17282
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
A430005L14Rik-flox
Strain ID
CKOCMP-97159-A430005L14Rik-B6J-VA
Gene Name
Product ID
S-CKO-17282
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-A430005L14Rikem1flox/Cya mice (Catalog S-CKO-17282) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058393
NCBI RefSeq
NM_175287
Target Region
Exon 2~3
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
A430005L14Rik, also known as C1orf174, was identified as a candidate gene in genome-wide association studies of age-related hearing loss (ARHL). Its specific essential function, associated pathways remain relatively unknown, but genetic models like mouse models can be valuable for studying its role in biological processes related to hearing [1].
In a study, the expression levels of A430005L14Rik were knocked down in mice to analyze auditory function. The A430005L14Rik (C1orf174) mutants showed worse recovery from noise-induced damage than controls, indicating its possible role in the process of recovery from noise-related hearing damage [1].
In conclusion, A430005L14Rik plays a role in the recovery from noise-induced hearing damage as revealed through gene-knockout mouse model-based research. This finding contributes to understanding the genetic basis of age-related hearing loss, providing insights into the disease mechanism and potentially new directions for treatment and prevention [1].
References：
1. Ingham, Neil J, Rook, Victoria, Di Domenico, Francesca, Buniello, Annalisa, Steel, Karen P. 2020. Functional analysis of candidate genes from genome-wide association studies of hearing. In Hearing research, 387, 107879. doi:10.1016/j.heares.2019.107879. https://pubmed.ncbi.nlm.nih.gov/31927188/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen