Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cntnap2em1flox/Cya
Common Name:
Cntnap2-flox
Product ID:
S-CKO-17468
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cntnap2-flox
Strain ID
CKOCMP-66797-Cntnap2-B6J-VA
Gene Name
Cntnap2
Product ID
S-CKO-17468
Gene Alias
5430425M22Rik; Caspr2; mKIAA0868
Background
C57BL/6JCya
NCBI ID
66797
Modification
Conditional knockout
Chromosome
6
Phenotype
MGI:1914047
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cntnap2em1flox/Cya mice (Catalog S-CKO-17468) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114641
NCBI RefSeq
NM_001004357
Target Region
Exon 3
Size of Effective Region
~3.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cntnap2, or contactin associated protein like 2, encodes a single transmembrane protein with 1331 amino acid residues. It is specifically expressed in the nervous system and plays versatile roles in axonal organization, synaptic functions, neuronal migration, and functional connectivity [2,7]. CNTNAP2 has been widely investigated as a risk gene for multiple neurodevelopmental disorders, including autism spectrum disorders (ASD), epilepsy, and others [1,2,4,5,6]. Mouse models based on human disease-causing mutations in Cntnap2 provide the potential for understanding its gene function and for developing novel treatments [1].

Cntnap2 knockout (KO) mice exhibit deficits in the three core ASD behavioral domains, hyperactivity, and epileptic seizures, paralleling human phenotypes with CNTNAP2 mutations. Neuropathological and physiological analyses before seizure onset in these mice show neuronal migration abnormalities, a reduced number of interneurons, and abnormal neuronal network activity [1]. Virally delivering the CNTNAP2 intracellular domain (CICD), produced by γ-secretase cleavage, to the medial prefrontal cortex of Cntnap2-deficient mice normalizes ASD-related behavioral deficits [2]. Oxytocin administration to Cntnap2 KO mice rescues social deficits, normalizes connectivity patterns, and restores oxytocin immunoreactivity in the paraventricular nucleus of the hypothalamus [3,5]. Intragenic deletions of CNTNAP2 may disrupt its ability to bridge the intercellular space between neurons, potentially contributing to neuronal hypoconnectivity in neurodevelopmental disorders [4].

In conclusion, model-based research reveals that Cntnap2 is crucial for proper brain development and normal neuronal function. Cntnap2 KO mouse models have significantly contributed to understanding the role of Cntnap2 in ASD and other neurodevelopmental disorders, providing new tools for mechanistic and therapeutic research in these disease areas [1,2,3,4,5].

References:
1. Peñagarikano, Olga, Abrahams, Brett S, Herman, Edward I, Peles, Elior, Geschwind, Daniel H. . Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. In Cell, 147, 235-46. doi:10.1016/j.cell.2011.08.040. https://pubmed.ncbi.nlm.nih.gov/21962519/
2. Zhang, Jing, Cai, Fang, Lu, Renbin, Song, Weihong, Li, Jia-Da. 2023. CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors. In Signal transduction and targeted therapy, 8, 219. doi:10.1038/s41392-023-01431-6. https://pubmed.ncbi.nlm.nih.gov/37271769/
3. Choe, Katrina Y, Bethlehem, Richard A I, Safrin, Martin, Harris, Neil G, Geschwind, Daniel H. 2021. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. In Neuron, 110, 795-808.e6. doi:10.1016/j.neuron.2021.11.031. https://pubmed.ncbi.nlm.nih.gov/34932941/
4. Poot, Martin. 2017. Intragenic CNTNAP2 Deletions: A Bridge Too Far? In Molecular syndromology, 8, 118-130. doi:10.1159/000456021. https://pubmed.ncbi.nlm.nih.gov/28588433/
5. Peñagarikano, Olga, Lázaro, María T, Lu, Xiao-Hong, Golshani, Peyman, Geschwind, Daniel H. . Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. In Science translational medicine, 7, 271ra8. doi:10.1126/scitranslmed.3010257. https://pubmed.ncbi.nlm.nih.gov/25609168/
6. Poot, Martin. 2015. Connecting the CNTNAP2 Networks with Neurodevelopmental Disorders. In Molecular syndromology, 6, 7-22. doi:10.1159/000371594. https://pubmed.ncbi.nlm.nih.gov/25852443/
7. Zhang, Qing, Sterling, Keenan, Xu, Lu, Bestard-Lorigados, Isabel, Song, Weihong. 2023. CNTNAP2 Protein Is Degraded by the Ubiquitin-Proteasome System and the Macroautophagy-Lysosome Pathway. In Molecular neurobiology, 60, 2455-2469. doi:10.1007/s12035-023-03227-9. https://pubmed.ncbi.nlm.nih.gov/36658382/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest