C57BL/6JCya-Cav1em1flox/Cya
Common Name:
Cav1-flox
Product ID:
S-CKO-17614
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cav1-flox
Strain ID
CKOCMP-12389-Cav1-B6J-VC
Gene Name
Product ID
S-CKO-17614
Gene Alias
Cav; Cav-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cav1em1flox/Cya mice (Catalog S-CKO-17614) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000007799
NCBI RefSeq
NM_007616
Target Region
Exon 1~2
Size of Effective Region
~3.8 kb
Detailed Document
Overview of Gene Research
Cav1, encoding caveolin-1, is a major protein of plasma membrane microdomains called caveolae. It is involved in several signaling pathways and located at the adipocyte lipid droplet [5]. Caveolin-1 has been shown to influence tumorigenicity, with its polymorphisms potentially related to cancer risks. It also plays roles in cell senescence, immune microenvironment regulation, and fibrosis-related processes [6,7,8]. Genetic models can help understand the functions of Cav1 and its polymorphisms in these biological processes.
In cancer-related studies, certain Cav1 polymorphisms such as rs1049334 are associated with an increased risk of urinary cancer, while rs1049337 and rs7804372 may act as protectors [1]. In breast cancer, rs3807987 and rs7804372 polymorphisms are related to the change of breast cancer risk [2]. In prostate cancer, Cav1 is highly expressed, and higher expression is associated with a worse prognosis [3]. In esophageal cancer, down-regulated Cav1 expression is related to a higher tumor mutation burden and a higher rate of response to immune checkpoint inhibitors [7]. In addition, Cav1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway, which is important in chronic allograft dysfunction [4]. In atrial fibrillation, Cav1 is critical for the MG53 regulation of TGF-β1 signaling pathway-induced atrial fibrosis [8].
In conclusion, Cav1 is a crucial protein involved in multiple biological processes and diseases. Studies on Cav1, especially those using genetic models, have revealed its significant roles in cancer, fibrosis-related diseases, and other conditions. Understanding Cav1's functions provides insights into disease mechanisms and potential therapeutic targets.
References:
1. Fan, Song, Meng, Jialin, Zhang, Li, Zhang, Xiansheng, Liang, Chaozhao. 2018. CAV1 polymorphisms rs1049334, rs1049337, rs7804372 might be the potential risk in tumorigenicity of urinary cancer: A systematic review and meta-analysis. In Pathology, research and practice, 215, 151-158. doi:10.1016/j.prp.2018.11.009. https://pubmed.ncbi.nlm.nih.gov/30463805/
2. Yan, Cunye, Sun, Chenyu, Ding, Xiuxiu, Chen, Ying, Wang, Benzhong. 2019. Association of CAV1 polymorphisms with the risks of breast cancer: A systematic review and meta-analysis. In Pathology, research and practice, 215, 152518. doi:10.1016/j.prp.2019.152518. https://pubmed.ncbi.nlm.nih.gov/31303379/
3. Guo, Liuxiong, Liu, Yixuan, Yang, Tao, Liu, Bin, Cai, Jianhui. . CAV1 and KRT5 are potential targets for prostate cancer. In Medicine, 102, e36473. doi:10.1097/MD.0000000000036473. https://pubmed.ncbi.nlm.nih.gov/38065913/
4. Han, Qianguang, Ni, Bin, Bao, Wei, Ju, Xiaobing, Tan, Ruoyun. 2025. CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway. In Frontiers in immunology, 16, 1523855. doi:10.3389/fimmu.2025.1523855. https://pubmed.ncbi.nlm.nih.gov/40013149/
5. Karhan, Asuman Nur, Zammouri, Jamila, Auclair, Martine, Jéru, Isabelle, Vigouroux, Corinne. 2021. Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia. In European journal of endocrinology, 185, 841-854. doi:10.1530/EJE-21-0915. https://pubmed.ncbi.nlm.nih.gov/34643546/
6. Zhang, Shuo, Zhu, Neng, Shi, Ya-Ning, Li, Hong-Fang, Qin, Li. 2024. Celastrol mediates CAV1 to attenuate pro-tumorigenic effects of senescent cells. In Phytomedicine : international journal of phytotherapy and phytopharmacology, 129, 155614. doi:10.1016/j.phymed.2024.155614. https://pubmed.ncbi.nlm.nih.gov/38692078/
7. Zhang, Runan, Wang, Haizhou, Xiao, Jun, Huang, Tizheng, Zhao, Qiu. 2022. CAV1 Impacts the Tumor Immune Microenvironment and Has Potential Value of Predicting Response to Immunotherapy in Esophageal Cancer. In DNA and cell biology, 42, 27-42. doi:10.1089/dna.2022.0025. https://pubmed.ncbi.nlm.nih.gov/36638349/
8. Zhang, Meixia, Wang, Hechuan, Wang, Xiaowen, Lu, Kai, Xiao, Hua. 2020. MG53/CAV1 regulates transforming growth factor-β1 signaling-induced atrial fibrosis in atrial fibrillation. In Cell cycle (Georgetown, Tex.), 19, 2734-2744. doi:10.1080/15384101.2020.1827183. https://pubmed.ncbi.nlm.nih.gov/33000676/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen