C57BL/6JCya-Lynem1flox/Cya
Common Name
Lyn-flox
Product ID
S-CKO-17657
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-17096-Lyn-B6J-VB
When using this mouse strain in a publication, please cite “Lyn-flox Mouse (Catalog S-CKO-17657) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lyn-flox
Strain ID
CKOCMP-17096-Lyn-B6J-VB
Gene Name
Product ID
S-CKO-17657
Gene Alias
Hck-2, p53Lyn, p56Lyn
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000041377
NCBI RefSeq
NM_001111096
Target Region
Exon 3~7
Size of Effective Region
~4.9 kb
Overview of Gene Research
Lyn, also known as Lck/yes-related protein tyrosine kinase, belongs to the Src family kinases (SFKs). It plays numerous biological functions, such as modulating receptor-mediated intracellular signaling and intercellular communication, and is essential in immunoreceptor signaling pathways [2,3]. Lyn is involved in multiple pathways like the IgE/FcεRI signaling pathway regulating allergy [3], and has a role in the development and function of B lymphocytes and myeloid immune cells [2,4,5].
Lyn-deficient mouse models have revealed its significance in various disease conditions. Lyn-/-mice develop an SLE-like disease with plasma cell hyperplasia, highlighting its role in tightly regulating signaling within B cells in systemic lupus erythematosus (SLE) [4,5,7]. In sepsis-associated acute kidney injury (SA-AKI), Lyn protected against renal tubular injury in a cecal ligation and puncture (CLP) induced AKI mouse model by inhibiting STAT3 phosphorylation and cell apoptosis [1]. Also, pharmacological inhibition or genetic depletion of Lyn in cells blocked the secretion of Dengue and Zika infectious particles, indicating its role in flavivirus egress [6].
In conclusion, Lyn is a crucial regulator in multiple biological processes and diseases. Model-based research, especially using Lyn knockout mouse models, has been instrumental in uncovering its role in diseases such as SLE, SA-AKI, and flavivirus-related conditions, providing insights into potential therapeutic targets.
References：
1. Li, Nannan, Lin, Guoxin, Zhang, Hao, Liu, Jishi, Tang, Juan. 2023. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. In Biochemical pharmacology, 211, 115523. doi:10.1016/j.bcp.2023.115523. https://pubmed.ncbi.nlm.nih.gov/37003346/
2. Brian, Ben F, Freedman, Tanya S. . The Src-family Kinase Lyn in Immunoreceptor Signaling. In Endocrinology, 162, . doi:10.1210/endocr/bqab152. https://pubmed.ncbi.nlm.nih.gov/34320188/
3. Sun, Yizhao, Yang, Yanlei, Zhao, Yang, Zhang, Yanfen, Liu, Zhongcheng. 2021. The role of the tyrosine kinase Lyn in allergy and cancer. In Molecular immunology, 131, 121-126. doi:10.1016/j.molimm.2020.12.028. https://pubmed.ncbi.nlm.nih.gov/33419562/
4. Brodie, Erica J, Infantino, Simona, Low, Michael S Y, Tarlinton, David M. 2018. Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity. In Frontiers in immunology, 9, 401. doi:10.3389/fimmu.2018.00401. https://pubmed.ncbi.nlm.nih.gov/29545808/
5. Xu, Yuekang, Harder, Kenneth W, Huntington, Nicholas D, Hibbs, Margaret L, Tarlinton, David M. . Lyn tyrosine kinase: accentuating the positive and the negative. In Immunity, 22, 9-18. doi:. https://pubmed.ncbi.nlm.nih.gov/15664155/
6. Li, Ming Yuan, Naik, Trupti Shivaprasad, Siu, Lewis Yu Lam, Evans, Matthew J, Sanyal, Sumana. 2020. Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. In Nature communications, 11, 5189. doi:10.1038/s41467-020-19028-w. https://pubmed.ncbi.nlm.nih.gov/33060596/
7. L'Estrange-Stranieri, Elan, Gottschalk, Timothy A, Wright, Mark D, Hibbs, Margaret L. 2024. The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus. In Frontiers in immunology, 15, 1395427. doi:10.3389/fimmu.2024.1395427. https://pubmed.ncbi.nlm.nih.gov/39007135/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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