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C57BL/6NCya-Mynnem1flox/Cya
Common Name:
Mynn-flox
Product ID:
S-CKO-17670
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mynn-flox
Strain ID
CKOCMP-80732-Mynn-B6N-VB
Gene Name
Mynn
Product ID
S-CKO-17670
Gene Alias
2810011C24Rik; Mynr; SBBIZ1
Background
C57BL/6NCya
NCBI ID
80732
Modification
Conditional knockout
Chromosome
3
Phenotype
MGI:1931415
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Mynnem1flox/Cya mice (Catalog S-CKO-17670) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000192715
NCBI RefSeq
NM_030557
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MYNN, also known as myoneurin, is a gene encoding a BTB/POZ and zinc finger protein. It is involved in regulating BMP signaling. Mynn interacts with Smad proteins in the nucleus, disrupting the association between Smad protein and the phosphatase Ppm1a, preventing Smad dephosphorylation, which is crucial for proper BMP signal activity during tissue formation and organogenesis [2].

In a Turkish population study, the polymorphism of MYNN rs10936599 was found to be in linkage disequilibrium with SNPs in the 3q26.2 chromosomal region, and had a strong cumulative association with bladder cancer risk. Patients with certain genotypes (CT, CT+TT) had a decreased risk, while the CC genotype had a two-times increased risk ratio for bladder cancer [1]. In a GWAS meta-analysis on female genital tract polyps, MYNN was prioritized as a gene involved in DNA repair, cell proliferation, and cell growth [3]. In an ovarian cancer study, MYNN was identified as a novel potential driver through integrated copy number and expression analysis [4]. A study on colorectal cancer patients found that the rs10936599 SNP at MYNN was significantly associated with disease-free survival or overall survival [5].

In summary, MYNN plays important roles in multiple biological processes and is associated with various diseases including bladder cancer, female genital tract polyps, ovarian cancer, and colorectal cancer. These disease-related associations highlight the significance of MYNN in understanding disease mechanisms, which may potentially contribute to better diagnosis, risk assessment, and treatment strategies.

References:
1. Polat, Fikriye, Yilmaz, Meral, Budak Diler, Songul. 2019. The Association of MYNN and TERC Gene Polymorphisms and Bladder Cancer in a Turkish Population. In Urology journal, 16, 50-55. doi:10.22037/uj.v0i0.4083. https://pubmed.ncbi.nlm.nih.gov/30120764/
2. Yang, Shuyan, Ning, Guozhu, Hou, Yiming, Zhang, Ting, Wang, Qiang. 2022. Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. In iScience, 25, 104495. doi:10.1016/j.isci.2022.104495. https://pubmed.ncbi.nlm.nih.gov/35712083/
3. Pathare, Amruta D S, Džigurski, Jelisaveta, Pujol-Gualdo, Natàlia, Saare, Merli, Laisk, Triin. . A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth. In Human reproduction (Oxford, England), 40, 750-763. doi:10.1093/humrep/deaf025. https://pubmed.ncbi.nlm.nih.gov/39986329/
4. Ramakrishna, Manasa, Williams, Louise H, Boyle, Samantha E, Gorringe, Kylie L, Campbell, Ian G. 2010. Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. In PloS one, 5, e9983. doi:10.1371/journal.pone.0009983. https://pubmed.ncbi.nlm.nih.gov/20386695/
5. Song, Nan, Kim, Kyeezu, Shin, Aesun, Zheng, Wei, Oh, Jae Hwan. 2018. Colorectal cancer susceptibility loci and influence on survival. In Genes, chromosomes & cancer, 57, 630-637. doi:10.1002/gcc.22674. https://pubmed.ncbi.nlm.nih.gov/30350386/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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