C57BL/6NCya-Ptprsem1flox/Cya
Common Name:
Ptprs-flox
Product ID:
S-CKO-17693
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ptprs-flox
Strain ID
CKOCMP-19280-Ptprs-B6N-VB
Gene Name
Product ID
S-CKO-17693
Gene Alias
PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9; R-PTP-S; RPTPsigma
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ptprsem1flox/Cya mice (Catalog S-CKO-17693) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067538
NCBI RefSeq
NM_011218
Target Region
Exon 4~5
Size of Effective Region
~3.2 kb
Detailed Document
Overview of Gene Research
Ptprs, also known as protein tyrosine phosphatase receptor sigma, is a receptor-type protein tyrosine phosphatase. It plays roles in multiple biological processes by regulating cell migration, invasion, and the activation of various signaling pathways such as the RAS-ERK pathway. It is involved in maintaining synaptic integrity and is related to the epithelial-mesenchymal transition (EMT) process [1-4, 6, 8].
In NF1-related plexiform neurofibromas, reduced PTPRS expression promotes the EMT of Schwann cells, and this is associated with tumor recurrence. PTPRS knockdown can promote EGFR expression and phosphorylation, and restoring the disrupted EMT processes by EGFR knockdown or using an EGFR inhibitor [1].
In Alzheimer's disease, the PTPRS rs10415488 variant C shows neuroprotective features against early tau pathology and synaptic degeneration, with a sexual dimorphism observed where male carriers have a delayed disease onset [2,4].
In colorectal cancer, PTPRS mutations can reduce its phosphatase activity, increasing ERK activation and downstream signaling [3,5].
In glioblastoma, loss of PTPRS leads to potent metastatic capability and resistance to temozolomide [6].
In conclusion, Ptprs is crucial in regulating cell behavior and signaling pathways. Studies using models with PTPRS alterations, like knockdown or mutation models, have revealed its significant roles in diseases such as neurofibromas, Alzheimer's disease, colorectal cancer, and glioblastoma, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Li, Yuehua, Liu, Jun, Huang, Jingxuan, Li, Qingfeng, Wang, Zhichao. 2024. Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas. In Cancer letters, 599, 217151. doi:10.1016/j.canlet.2024.217151. https://pubmed.ncbi.nlm.nih.gov/39094827/
2. Poirier, Alexandre, Picard, Cynthia, Labonté, Anne, Tremblay, Michel L, Poirier, Judes. 2024. PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer's disease. In Scientific reports, 14, 14718. doi:10.1038/s41598-024-65104-2. https://pubmed.ncbi.nlm.nih.gov/38926456/
3. Davis, Thomas B, Yang, Mingli, Wang, Heiman, Yeatman, Timothy J, Pledger, W Jack. 2019. PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC. In Oncotarget, 10, 6768-6780. doi:10.18632/oncotarget.27335. https://pubmed.ncbi.nlm.nih.gov/31827720/
4. Poirier, Alexandre, Picard, Cynthia, Labonté, Anne, Tremblay, Michel L, Poirier, Judes. 2024. PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer's disease. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.05.12.593733. https://pubmed.ncbi.nlm.nih.gov/38766183/
5. Davis, Thomas B, Yang, Mingli, Schell, Michael J, Pledger, W Jack, Yeatman, Timothy J. 2018. PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation. In Scientific reports, 8, 9296. doi:10.1038/s41598-018-27584-x. https://pubmed.ncbi.nlm.nih.gov/29915291/
6. Zhang, Yihua, Chang, Liugang, Huang, Ping, He, Xuzhi, Xu, Lunshan. 2024. Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma. In Molecular carcinogenesis, 63, 1235-1247. doi:10.1002/mc.23720. https://pubmed.ncbi.nlm.nih.gov/38517048/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen