C57BL/6NCya-Rmnd5bem1flox/Cya
Common Name:
Rmnd5b-flox
Product ID:
S-CKO-17700
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rmnd5b-flox
Strain ID
CKOCMP-66089-Rmnd5b-B6N-VB
Gene Name
Product ID
S-CKO-17700
Gene Alias
0610039K22Rik; Gid2
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Rmnd5bem1flox/Cya mice (Catalog S-CKO-17700) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001081
NCBI RefSeq
NM_025346
Target Region
Exon 3~7
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
Rmnd5b is a member of the CTLH (carboxy-terminal to LisH) complex, a mammalian macromolecular complex with E3-ligase enzymatic activity. The CTLH complex is involved in fundamental biological processes such as proliferation, survival, programmed cell death, cell adhesion, and migration, and interacts with key signaling pathways like PI3-kinase, WNT, TGFβ, and NFκB [1].
In esophageal squamous cell carcinoma (ESCC), bioinformatic analysis identified RMND5B as a prognosis-related gene, and the high-risk group based on the risk score including RMND5B was more responsive to immunotherapy [2]. In pancreatic adenocarcinoma (PAAD), a ZNF family genes-related risk score model including RMND5B was constructed, and the risk score was a significant independent prognostic factor [3]. In acute myeloid leukemia (AML), a prognostic model including RMND5B was established, which accurately predicted AML prognosis [4].
In conclusion, RMND5B, as part of the CTLH complex, is involved in multiple fundamental biological processes and key signaling pathways. Its role in ESCC, PAAD, and AML prognosis, as revealed through bioinformatic analysis and model-based research, highlights its importance in understanding these diseases and potentially developing new treatment strategies.
References：
1. Huffman, Nickelas, Palmieri, Dario, Coppola, Vincenzo. 2019. The CTLH Complex in Cancer Cell Plasticity. In Journal of oncology, 2019, 4216750. doi:10.1155/2019/4216750. https://pubmed.ncbi.nlm.nih.gov/31885576/
2. Wang, Xian, Peng, Wei, Zhao, Yali, Huang, Shan, Wang, Hua. 2024. Immune cell related signature predicts prognosis in esophageal squamous cell carcinoma based on single-cell and bulk-RNA sequencing. In Frontiers in oncology, 14, 1370801. doi:10.3389/fonc.2024.1370801. https://pubmed.ncbi.nlm.nih.gov/38903709/
3. Zhu, Lei, Tu, Dong, Li, Ruixue, Li, Tiehan, Zhu, Hong. 2023. The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study. In Frontiers in genetics, 14, 1089023. doi:10.3389/fgene.2023.1089023. https://pubmed.ncbi.nlm.nih.gov/37396042/
4. Ling, Chun, Cao, Nengneng, Wang, Huiping, Zhang, Qiguo, Zhai, Zhimin. 2025. Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia. In International journal of general medicine, 18, 459-472. doi:10.2147/IJGM.S502644. https://pubmed.ncbi.nlm.nih.gov/39895829/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen