C57BL/6JCya-Slc2a9em1flox/Cya
Common Name:
Slc2a9-flox
Product ID:
S-CKO-17709
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc2a9-flox
Strain ID
CKOCMP-117591-Slc2a9-B6J-VC
Gene Name
Product ID
S-CKO-17709
Gene Alias
GLUT-9; Glut9; SLC2A9B; SLC2a9A
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc2a9em1flox/Cya mice (Catalog S-CKO-17709) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067886
NCBI RefSeq
NM_001102414
Target Region
Exon 4
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Slc2a9, also known as GLUT9, is a gene encoding a transporter that plays a crucial role in regulating serum urate levels. It is mainly expressed in the renal tubules and is involved in uric acid (UA) absorption. Serum urate regulation by transporters like Slc2a9 is essential for preventing diseases related to abnormal urate levels. Genetic models can be valuable in studying its function [1,2].
A study constructed kidney organoids bearing an Slc2a9 missense mutation (rs16890979). These organoids showed reduced UA absorption, and UA absorption was increased in organoids with Slc2a9 overexpression and decreased with knockdown, suggesting GLUT9's role in UA absorption [2]. Meta-analyses found that certain Slc2a9 gene polymorphisms (rs12510549, rs16890979, rs1014290) protect against gout development in Caucasians and/or Asians, while rs3733591 may be a susceptibility SNP in Asians [3,4].
In conclusion, Slc2a9 is essential for uric acid absorption and regulation of serum urate levels. Studies using kidney organoids and meta-analyses of gene polymorphisms have revealed its role in gout susceptibility. Understanding Slc2a9's function through such model-based research provides insights into the mechanisms of hyperuricemia-related diseases like gout, potentially guiding future treatment strategies.
References：
1. Dalbeth, Nicola, Gosling, Anna L, Gaffo, Angelo, Abhishek, Abhishek. 2021. Gout. In Lancet (London, England), 397, 1843-1855. doi:10.1016/S0140-6736(21)00569-9. https://pubmed.ncbi.nlm.nih.gov/33798500/
2. Wu, Shouhai, Li, Chuang, Li, Yizhen, Zeng, Xiang, Mao, Wei. 2024. SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids. In Frontiers in cell and developmental biology, 11, 1268226. doi:10.3389/fcell.2023.1268226. https://pubmed.ncbi.nlm.nih.gov/38269090/
3. Zhang, Xu, Yang, Xiao, Wang, Mengmeng, Zou, Yanfeng, Pan, Faming. 2016. Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis. In Rheumatology international, 36, 1157-65. doi:10.1007/s00296-016-3503-6. https://pubmed.ncbi.nlm.nih.gov/27255295/
4. Lee, Y H, Seo, Y H, Kim, J-H, Ji, J D, Song, G G. . Associations between SLC2A9 polymorphisms and gout susceptibility : A meta-analysis. In Zeitschrift fur Rheumatologie, 76, 64-70. doi:10.1007/s00393-016-0070-x. https://pubmed.ncbi.nlm.nih.gov/27052299/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen